Table of Contents
Computational Biology Journal
Volume 2013, Article ID 301369, 26 pages
Research Article

A Composite Synergistic Systems Model for Exploring the Efficacies of Different Chemotherapeutic Strategies in Cancer

1Department of Physiology, West Bengal State University, Berunanpukuria, Malikapur, Barasat, 24 Pgs (N), Kolkata 700 126, India
2Deptartment of Electronics and Communication Engineering, Bengal College of Engineering & Technology, Sahid Sukumar Banerjee Sarani, Bidhannagar, Durgapur, Burdwan, West Bengal 713212, India

Received 17 June 2013; Revised 26 August 2013; Accepted 27 August 2013

Academic Editor: Marie-Veronique Clement

Copyright © 2013 Probir Kumar Dhar and Durjoy Majumder. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Different chemotherapeutic strategies like Maximum Tolerable Dosing (MTD), Metronomic Chemotherapy (MCT), and Antiangiogenic (AAG) drug are available; however, the selection of the best therapeutic strategy for an individual patient remains uncertain till now. Several analytical models are proposed for each of the chemotherapeutic strategies; however, no single analytical model is available which can make a comparative assessment regarding the long-term therapeutic efficacy among these strategies. This, in turn, may limit the clinical application of such analytical models. To address this issue here we developed a composite synergistic system (CSS) model. Through this CSS model, comparative assessment among the MTD, MCT, and AAG drug therapy can be assessed. Moreover, these chemotherapeutic strategies along with different supportive therapies like Hematopoietic Stem Cell transplantation (HSC), cellular immunotherapy as well as different combinations among these therapeutic strategies can be assessed. Fitting of initial clinical data of individual clinical cases to this analytical model followed by simulation runs may help in making such decision. Analytical assessments suggest that with the considered tumor condition MCT alone could be more effective one than any other therapeutics and/or their combinations for controlling the long-term tumor burden.