Table of Contents
Computational Biology Journal
Volume 2013, Article ID 301369, 26 pages
http://dx.doi.org/10.1155/2013/301369
Research Article

A Composite Synergistic Systems Model for Exploring the Efficacies of Different Chemotherapeutic Strategies in Cancer

1Department of Physiology, West Bengal State University, Berunanpukuria, Malikapur, Barasat, 24 Pgs (N), Kolkata 700 126, India
2Deptartment of Electronics and Communication Engineering, Bengal College of Engineering & Technology, Sahid Sukumar Banerjee Sarani, Bidhannagar, Durgapur, Burdwan, West Bengal 713212, India

Received 17 June 2013; Revised 26 August 2013; Accepted 27 August 2013

Academic Editor: Marie-Veronique Clement

Copyright © 2013 Probir Kumar Dhar and Durjoy Majumder. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. Folkman, “Role of angiogenesis in tumor growth and metastasis,” Seminars in Oncology, vol. 29, no. 6, pp. 15–18, 2002. View at Google Scholar · View at Scopus
  2. R. S. Kerbel and J. Folkman, “Clinical translation of angiogenesis inhibitors,” Nature Reviews Cancer, vol. 2, no. 10, pp. 727–739, 2002. View at Publisher · View at Google Scholar · View at Scopus
  3. N. Ferrara, “Vascular endothelial growth factor as a target for anticancer therapy,” The Oncologist, vol. 9, supplement 1, pp. 2–10, 2004. View at Publisher · View at Google Scholar · View at Scopus
  4. R. S. Kerbel and B. A. Kamen, “The anti-angiogenic basis of metronomic chemotherapy,” Nature Reviews Cancer, vol. 4, no. 6, pp. 423–436, 2004. View at Google Scholar · View at Scopus
  5. E. A. Donovan and S. Kummar, “Targeting VEGF in cancer therapy,” Current Problems in Cancer, vol. 30, no. 1, pp. 7–32, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. T. Y. Chen, H. H. W. Chen, W. C. Su, and C. J. Tsao, “High-dose chemotherapy and hematopoietic stem cell transplantation for patients with nasopharyngeal cancer: a feasibility study,” Japanese Journal of Clinical Oncology, vol. 33, no. 7, pp. 331–335, 2003. View at Publisher · View at Google Scholar · View at Scopus
  7. K. H. Antman, P. A. Rowlings, W. P. Vaughan et al., “High-dose chemotherapy with autologous hematopoietic stem-cell support for breast cancer in North America,” Journal of Clinical Oncology, vol. 15, no. 5, pp. 1870–1879, 1997. View at Google Scholar · View at Scopus
  8. L. E. Damon, W. W. Hu, K. E. Stockerl-Goldstein et al., “High-dose chemotherapy and hematopoietic stem cell rescue for breast cancer: experience in California,” Biology of Blood and Marrow Transplantation, vol. 6, no. 5, pp. 496–505, 2000. View at Google Scholar · View at Scopus
  9. J. P. Lotz, H. Curé, M. Janvier et al., “High-dose chemotherapy with haematopoietic stem cell transplantation for metastatic breast cancer patients: final results of the French multicentric randomised CMA/PEGASE 04 protocol,” European Journal of Cancer, vol. 41, no. 1, pp. 71–80, 2005. View at Publisher · View at Google Scholar · View at Scopus
  10. D. E. Adelberg and M. R. Bishop, “Emergencies related to cancer chemotherapy and hematopoietic stem cell transplantation,” Emergency Medicine Clinics of North America, vol. 27, no. 2, pp. 311–331, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. D. A. Berry, N. T. Ueno, M. M. Johnson et al., “High-dose chemotherapy with autologous stem-cell support as adjuvant therapy in breast cancer: overview of 15 randomized trials,” Journal of Clinical Oncology, vol. 29, no. 24, pp. 3214–3223, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. A. A. Hamidieh, M. Jalili, O. Khojasteh, and A. Ghavamzadeh, “Autologous stem cell transplantation as treatment modality in a patient with relapsed pancreatoblastoma,” Pediatric Blood and Cancer, vol. 55, no. 3, pp. 573–576, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. M. R. Litzow, P. P. Peethambaram, S. L. Safgren et al., “Phase I trial of autologous hematopoietic SCT with escalating doses of topotecan combined with CY and carboplatin in patients with relapsed or persistent ovarian or primary peritoneal carcinoma,” Bone Marrow Transplantation, vol. 45, no. 3, pp. 490–497, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. H. Kaur and G. T. Budd, “Metronomic therapy for breast cancer,” Current Oncology Reports, vol. 6, no. 1, pp. 49–52, 2004. View at Publisher · View at Google Scholar · View at Scopus
  15. E. Pasquier, M. Kavallaris, and N. André, “Metronomic chemotherapy: new rationale for new directions,” Nature Reviews Clinical Oncology, vol. 7, no. 8, pp. 455–465, 2010. View at Publisher · View at Google Scholar · View at Scopus
  16. N. André, L. Padovani, and E. Pasquier, “Metronomic scheduling of anticancer treatment: the next generation of multitarget therapy?” Future Oncology, vol. 7, no. 3, pp. 385–394, 2011. View at Publisher · View at Google Scholar · View at Scopus
  17. P. Hahnfeldt, J. Folkman, and L. Hlatky, “Minimizing long-term tumor burden: the logic for metronomic chemotherapeutic dosing and its anti-angiogenic basis,” Journal of Theoretical Biology, vol. 220, no. 4, pp. 545–554, 2003. View at Publisher · View at Google Scholar · View at Scopus
  18. A. Mukherjee, D. Majumder, and A. Icbal, “Exploring the effectiveness of low continuous chemo-bio-therapeutic treatment of cancer through analytical system modelling,” Journal of Biological Systems, vol. 14, no. 1, pp. 1–12, 2006. View at Publisher · View at Google Scholar · View at Scopus
  19. A. Mukherjee and D. Majumder, “Pathophysiologically based logistics for treatment of cancer,” Journal of Biological Systems, vol. 14, no. 4, pp. 631–650, 2006. View at Publisher · View at Google Scholar · View at Scopus
  20. D. Majumder and A. Mukherjee, “Mathematical modelling of toxicity-related trade-offs in metronomic chemotherapy,” IET Systems Biology, vol. 1, no. 5, pp. 298–305, 2007. View at Publisher · View at Google Scholar · View at Scopus
  21. A. Mukherjee and D. Majumder, “Mathematical modelling for the assessment of the effect of drug application delays in metronomic chemotherapy of cancer due to physiological constraints,” BioSystems, vol. 91, no. 1, pp. 108–116, 2008. View at Publisher · View at Google Scholar · View at Scopus
  22. S. Bhattacharya and D. Majumder, “An analytical approach for tracking the tumor system dynamics,” in Proceedings of the World Congress on Nature & Biologically Inspired Computing (NaBIC '09), IEEE Catalogue Number: CFP0995H-CDR, pp. 92–97, December 2009, Library of Congress: 2009907135.
  23. D. Majumder, “Tumor angiogenesis based analytical model for the assessment of MCT and MTD chemotherapeutic strategies in cancer,” Journal of Biological Systems, vol. 18, no. 4, pp. 749–761, 2010. View at Publisher · View at Google Scholar · View at Scopus
  24. D. Majumder and A. Mukherjee, “A passage through systems biology to systems medicine: adoption of middle-out rational approaches towards the understanding of therapeutic outcomes in cancer,” Analyst, vol. 136, no. 4, pp. 663–678, 2011. View at Publisher · View at Google Scholar · View at Scopus
  25. A. Mukherjee and D. Majumder, “Dynamical model for assessment of anti-angiogenic therapy of cancer,” Molecular BioSystems, vol. 6, no. 6, pp. 1047–1055, 2010. View at Publisher · View at Google Scholar · View at Scopus
  26. V. Gregorc, A. Santoro, E. Bennicelli et al., “Phase Ib study of NGR-hTNF, a selective vascular targeting agent, administered at low doses in combination with doxorubicin to patients with advanced solid tumours,” British Journal of Cancer, vol. 101, no. 2, pp. 219–224, 2009. View at Publisher · View at Google Scholar · View at Scopus
  27. M. Garcia-Barros, F. Paris, C. Cordon-Cardo et al., “Tumor response to radiotherapy regulated by endothelial cell apoptosis,” Science, vol. 300, no. 5622, pp. 1155–1159, 2003. View at Publisher · View at Google Scholar · View at Scopus
  28. J. M. L. Ebos, C. R. Lee, and R. S. Kerbel, “Tumor and host-mediated pathways of resistance and disease progression in response to antiangiogenic therapy,” Clinical Cancer Research, vol. 15, no. 16, pp. 5020–5025, 2009. View at Publisher · View at Google Scholar · View at Scopus
  29. F. Azam, S. Mehta, and A. L. Harris, “Mechanisms of resistance to antiangiogenesis therapy,” European Journal of Cancer, vol. 46, no. 8, pp. 1323–1332, 2010. View at Publisher · View at Google Scholar · View at Scopus
  30. E. Pasquier, M. W. Kieran, J. Sterba et al., “Moving forward with metronomic chemotherapy: meeting report of the 2nd International Workshop on Metronomic and Anti-Angiogenic Chemotherapy in Paediatric Oncology,” Translational Oncology, vol. 4, no. 4, pp. 203–211, 2011. View at Google Scholar · View at Scopus
  31. J. M. L. Ebos and R. S. Kerbel, “Antiangiogenic therapy: impact on invasion, disease progression, and metastasis,” Nature Reviews Clinical Oncology, vol. 8, no. 4, pp. 210–221, 2011. View at Publisher · View at Google Scholar · View at Scopus
  32. D. H. Roukos, “Beyond HER2 and trastuzumab: heterogeneity, systems biology, and cancer origin research may guide the future for personalized treatment of very early but aggressive breast cancer,” Journal of Clinical Oncology, vol. 28, no. 17, pp. e279–e280, 2010. View at Publisher · View at Google Scholar · View at Scopus
  33. A. H. Chauviere, H. Hatzikirou, J. S. Lowengrub, H. B. Frieboes, A. M. Thompson, and V. Cristini, “Mathematical oncology: how are the mathematical and physical sciences contributing to the war on breast cancer?” Current Breast Cancer Reports, vol. 2, no. 3, pp. 121–129, 2010. View at Publisher · View at Google Scholar · View at Scopus
  34. L. B. Edelman, J. A. Eddy, and N. D. Price, “In silico models of cancer,” Wiley Interdisciplinary Reviews, vol. 2, no. 4, pp. 438–459, 2010. View at Publisher · View at Google Scholar · View at Scopus
  35. F. Levi, E. Mosekilde, and D. A. Rand, “Advancing systems medicine and therapeutics through biosimulation,” Interface Focus, vol. 1, no. 1, pp. 3–6, 2011. View at Publisher · View at Google Scholar
  36. R. Bruno, J. F. Lu, Y. N. Sun, and L. Claret, “A modeling and simulation framework to support early clinical drug development decisions in oncology,” Journal of Clinical Pharmacology, vol. 51, no. 1, pp. 6–8, 2011. View at Publisher · View at Google Scholar · View at Scopus
  37. R. A. Gatenby, “A change of strategy in the war on cancer,” Nature, vol. 459, no. 7246, pp. 508–509, 2009. View at Publisher · View at Google Scholar · View at Scopus