Table of Contents
Computational Biology Journal
Volume 2013 (2013), Article ID 795418, 10 pages
Research Article

Transition and Transversion on the Common Trinucleotide Circular Code

Equipe de Bioinformatique Théorique, ICube, Université de Strasbourg, CNRS, 300 boulevard Sébastien Brant, 67400 Illkirch, France

Received 15 February 2013; Accepted 22 April 2013

Academic Editor: Alessandra Lumini

Copyright © 2013 Emmanuel Benard and Christian J. Michel. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


In 1996, a trinucleotide circular code which is maximum, self-complementary, and , called , was identified statistically on a large gene population of eukaryotes and prokaryotes (Arquès and Michel (1996)). Transition and transversions I and II are classical molecular evolution processes. A comprehensive computer analysis of these three evolution processes in the code shows some new results; in particular (i) transversion I on the 2nd position of any subset of trinucleotides of generates trinucleotide circular codes which are always and (ii) transversion II on the three positions of any subset of trinucleotides of yields no trinucleotide circular codes. These new results extend our theory of circular code in genes to its evolution under transition and transversion.