Activity of Antimicrobial Peptides and Conventional Antibiotics against Superantigen Positive Staphylococcus aureus Isolated from the Patients with Neoplastic and Inflammatory Erythrodermia

Table 1

The activity of antimicrobial peptides and conventional antibiotics against S. aureus clinical isolates.

Strain (no. of isolates) and agent	MIC (mg/liter)			MBC (mg/liter)
	Range	50%	90%	Range	50%	90%
Superantigen negative S. aureus (10)
Tachyplesin 3	1–4	2	4	2–4	2	4
Lipopeptide	1–8	2	4	2–8	4	8
Protegrin 1	1–4	2	4	2–8	4	8
Temporin A	8–32	8	16	16–64	16	32
Citropin 1.1	8–32	16	32	16–64	16	64
Aurein 1.2	32–128	64	128	64–128	64	128
Uperin 3.6	128–256	128	128	128-128	128	128
Rifampicin	0.25–1	0.25	1	1-2	0.25	1
Tigecycline	0.5–1	0.5	0.5	1-2	1	1
Linezolid	0.5–2	1	1	NT	NT	NT
Vancomycin	0.5–1	1	1	1–4	1	2
Daptomycin	1–4	1	2	1–4	2	2
Ciprofloxacin	0.25–0.5	0.25	0.5	1–8	1	4
Chloramphenicol	2–32	4	32	8–32	8	32
Erythromycin	0.25–64	0.5	0.5	1–4	1	2
Clindamycin	16–64	32	32	64–128	32	64
Superantigen positive S. aureus (14)
Tachyplesin 3	1–4	2	4	2–4	2	4
Lipopeptide	1–8	2	4	2–8	4	8
Protegrin 1	1–4	2	4	2–8	4	8
Temporin A	8–32	8	16	16–64	32	64
Citropin 1.1	8–32	16	32	16–64	16	64
Aurein 1.2	32–128	64	128	64–128	64	128
Uperin 3.6	128–256	128	128	128-128	128	128
Rifampicin	0.25–1	0.25	1	0.5–2	1	2
Tigecycline	0.5–1	0.5	0.5	1-2	1	1
Linezolid	0.5–2	1	2	NT	NT	NT
Vancomycin	0.5–2	1	2	1–4	2	4
Daptomycin	1–4	1	2	1–4	2	4
Ciprofloxacin	0.25–128	2	32	2–128	4	64
Chloramphenicol	4–128	8	64	8–128	16	128
Erythromycin	0.25–512	1	256	4–512	8	128
Clindamycin	8–512	64	512	16–512	64	128