Table 1

Comparison of cisplatin- and oxaliplatin-induced neurotoxicityCisplatinOxaliplatin

Dose limiting toxicityPeripheral neurotoxicityPeripheral neurotoxicity
SymptomsParesthesiaParesthesia, sensory ataxia, and dysesthesia
LocationExtremitiesExtremities, perioral area
Time-course onsetDelayedAcute and delayed
After treatmentdeteriorationRecovery
Accompanying toxicitiesOtotoxicityLaryngospasms
Precipitating factorsNoneExposure to cold