Review Article
Neurotoxicity Caused by the Treatment with Platinum Analogues
| Comparison of cisplatin- and oxaliplatin-induced neurotoxicity | Cisplatin | Oxaliplatin |
| Dose limiting toxicity | Peripheral neurotoxicity | Peripheral neurotoxicity | Symptoms | Paresthesia | Paresthesia, sensory ataxia, and dysesthesia | Location | Extremities | Extremities, perioral area | Time-course onset | Delayed | Acute and delayed | After treatment | deterioration | Recovery | Accompanying toxicities | Ototoxicity | Laryngospasms | Precipitating factors | None | Exposure to cold |
|
|