Table of Contents
Chemotherapy Research and Practice
Volume 2012, Article ID 198197, 15 pages
http://dx.doi.org/10.1155/2012/198197
Review Article

Antiepidermal Growth Factor Receptor Monoclonal Antibodies: Applications in Colorectal Cancer

1Beth Israel Medical Center, Phillips Ambulatory Care Center, Continuum Cancer Centers of New York, 10 Union Square East, Suite 4C, New York, NY, USA
2Section of Hematology/Oncology, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA

Received 16 April 2012; Accepted 12 June 2012

Academic Editor: Basil El-Rayes

Copyright © 2012 Efat Azizi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Patients with metastatic colorectal cancer have a poor prognosis and present a challenge to clinicians. The role of the antiepidermal growth factor receptor (EGFR) pathway in tumorogenesis and tumor progression has been well defined. This paper will review the use of anti-EGFR monoclonal antibodies in the treatment of operable, as well as metastatic colorectal cancer both in the setting of KRAS mutation unselected patients and later in KRAS wild-type patients. Active investigations designed to further identify predictive biomarkers that may be potentially druggable are reviewed as well.