Table of Contents
Chemotherapy Research and Practice
Volume 2012, Article ID 268681, 10 pages
Review Article

Extracellular Matrix Proteins Modulate Antimigratory and Apoptotic Effects of Doxorubicin

1UFR Pharmacie, FRE CNRS/URCA no. 3481, Université de Reims Champagne-Ardenne, 51096 Reims, Cedex, France
2UFR Medecine, FRE CNRS/URCA no. 3481, Université de Reims Champagne-Ardenne, 51096 Reims, Cedex, France
3UFR Sciences, FRE CNRS/URCA no. 3481, Université de Reims Champagne-Ardenne, 51687 Reims, Cedex 2, France

Received 3 February 2012; Accepted 30 April 2012

Academic Editor: Vassilios A. Georgoulias

Copyright © 2012 Georges Said et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Anticancer drug resistance is a multifactorial process that includes acquired and de novo drug resistances. Acquired resistance develops during treatment, while de novo resistance is the primary way for tumor cells to escape chemotherapy. Tumor microenvironment has been recently shown to be one of the important factors contributing to de novo resistance and called environment-mediated drug resistance (EMDR). Two forms of EMDR have been described: soluble factor-mediated drug resistance (SFM-DR) and cell adhesion-mediated drug resistance (CAM-DR). Anthracyclines, among the most potent chemotherapeutic agents, are widely used in clinics against hematopoietic and solid tumors. Their main mechanism of action relies on the inhibition of topoisomerase I and/or II and the induction of apoptosis. Beyond this well-known antitumor activity, it has been recently demonstrated that anthracyclines may display potent anti-invasive effects when used at subtoxic concentrations. In this paper, we will describe two particular modes of EMDR by which microenvironment may influence tumor-cell response to one of these anthracyclines, doxorubicin. The first one considers the influence of type I collagen on the antimigratory effect of doxorubicin (CAM-DR). The second considers the protection of tumor cells by thrombospondin-I against doxorubicin-induced apoptosis (SFM-DR).