Integrin Signaling in Cancer Cell Survival and Chemoresistance

<table>Laminin and fibronectin-mediated resistance to drug-induced apoptosis in breast cancer. Ligation of <i>α</i>3<i>β</i>1, <i>α</i>6<i>β</i>4, and <i>α</i>5<i>β</i>1 integrins with laminins and fibronectin, respectively, protects breast cancer cells from several cytotoxic agents <i>via</i> the activation of the PI 3-kinase/AKT and MAPK/ERK survival pathways.</table>

Chemotherapy Research and Practice

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Figure 1

Figure 1: Integrin Signaling in Cancer Cell Survival and Chemoresistance 