Integrin Signaling in Cancer Cell Survival and Chemoresistance

Figure 3

Model for collagen I/α2β1-dependent inhibition of AICD in T cells. Ligation of the α2β1 integrin in the context of TCR/CD3 activation leads to the synergistic activation of FAK, which leads to the reduction of TCR-induced Fas-L expression. Ligation of α2β1 with collagen I also induces the activation of the MAPK/ERK through the activation of Ras, protein phosphatase 2A (PP2A), and Raf-1. Active ERK inhibits Fas-induced signaling cascade by inhibiting caspase-8 processing and activation.