Induction Chemotherapy in Locally Advanced Pharyngolaryngeal Cancers with Stridor: Is It Feasible and Safe?

Table 3

Treatment details.

Patient	1	2	3	4	5	6	7	8
Regimen	D + C	D + carbo	P + carbo	P + carbo	P + carbo	DCF	DCF	D + C
Time for complete resolution of stridor (in hours)	24	24	48	48	24	24	24	24
Number of cycles	3	2	1	2	2	1	3	2
Response	SD	PR	PR	SD	PR	Not assessed	PR	PR
Grade 3-4 haematological toxicity	Nil	Yes	Nil	Nil	Nil	Nil	Yes	Yes
Grade 3-4 Gastrointestinal toxicity	Yes	Nil	Nil	Nil	Nil	Nil	Yes	Nil
% reduction in tumor size	10	47	37	20	40	Not assessed	80	37
Local Rx subsequently offered	CRT	CRT	RT	CRT	CRT	Defaulted	CRT	CRT

D: docetaxel, C: cisplatin, Pacli: paclitaxel, Carb: carboplatin, F: 5FU, CR: complete response, PR: partial response, SD: stable response, CRT: chemoradiation and RT: radical radiation.