Research Article

Preparation and In Vivo Evaluation of Dichloro(1,2-Diaminocyclohexane)platinum(II)-Loaded Core Cross-Linked Polymer Micelles

Figure 4

Cellular uptake and DNA platination.(a) Whole-cell Pt accumulation and (b) extent of DNA platination, following incubation with 1.0, 2.5, and 10 μM oxaliplatin (filled bars) or equivalent doses of DACHPt/cl-micelles (open bars) following 24 h exposure in A2780 cells as measured by ICP-MS. Values are mean ± standard deviation ( ).