Preparation and In Vivo Evaluation of Dichloro(1,2-Diaminocyclohexane)platinum(II)-Loaded Core Cross-Linked Polymer Micelles
In vivo efficacy of DACHPt/cl-micelles in A2780 human ovarian cancer xenograft-bearing female nude mice. Relative changes in (a) tumor volume and (b) body weight were measured following i.v. administration of (□) DACHPt/cl-micelles or (■) free oxaliplatin at 4 mg drug equivalents/kg body weight. Four administrations were given in total with each administration at every fourth day. Control group received 100 μL of 5% dextrose. Values are mean ± SEM ().