Research Article
Preparation and In Vivo Evaluation of Dichloro(1,2-Diaminocyclohexane)platinum(II)-Loaded Core Cross-Linked Polymer Micelles
Table 3
Clinical chemistry parameters from female C57Bl/6 micea.
| Treatment | ALT | AST | BUN | Creatinine | (U/L) | (U/L) | (mg/dL) | (mg/dL) |
| Normal rangeb | 17–77 | | 9–33 | 0.1–0.4 | Control | 26 ± 2.6 | 83 ± 8 | 13.3 ± 2.1 | |
| | | Oxaliplatin | | |
| 2 mg/kg | 29 ± 1.4 | 82 ± 27.6 | 14.7 ± 4 | 0.160 ± 0.017 c | 4 mg/kg | 32 ± 2.5 | 110 ± 47.5 c | 13.0 ± 1.0 | 0.157 ± 0.015 c | 6 mg/kg | 30 ± 1.0 | 88 ± 13.1 | 12.0 ± 1.7 | 0.160 ± 0.010 b |
| | DACHPt/cl-micelles | |
| 2 mg/kg | 45 ± 2.1 c | 149 ± 21.9 c | 12.0 ± 2.0 | | 4 mg/kg | 63 ± 3.0 c | 181 ± 36.9 c | 8.7 ± 0.6 | | 6 mg/kg | 43 ± 29.0 | 143 ± 51.6 | 10.7 ± 2.9 | |
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aValues are mean ± standard deviation ().
bAs reported by Roy et al. [20]
cSignificantly different from the controls ().
|