Research Article
Preparation and In Vivo Evaluation of Dichloro(1,2-Diaminocyclohexane)platinum(II)-Loaded Core Cross-Linked Polymer Micelles
Table 4
Tissue weight analysis at sacrifice from female C57Bl/6 micea.
| Treatment | Liver/BW | Spleen/BW | Kidney/BW |
| Control | 0.0448 ± 0.0039 | 0.0041 ± 0.0013 | 0.0142 ± 0.0007 |
| | Oxaliplatin | |
| 2 mg/kg | 0.0418 ± 0.0013 | 0.0028 ± 0.0007 | 0.0131 ± 0.0006 | 4 mg/kg | 0.0469 ± 0.0021 | 0.0021 ± 0.0003 | 0.0126 ± 0.0007 b | 6 mg/kg | 0.0459 ± 0.0025 | 0.0022 ± 0.0000 | 0.0130 ± 0.0004 b |
| | DACHPt/cl-micelles | |
| 2 mg/kg | 0.0471 ± 0.0041 | 0.0037 ± 0.0005 | 0.0140 ± 0.0007 | 4 mg/kg | 0.0542 ± 0.0025 b | 0.0040 ± 0.0007 | 0.0153 ± 0.0003 | 6 mg/kg | 0.0461 ± 0.0048 | 0.0038 ± 0.0005 | 0.0152 ± 0.0004 |
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aValues are mean ± standard deviation ().
bSignificantly different from the controls ().
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