Ferric Carboxymaltose-Mediated Attenuation of Doxorubicin-Induced Cardiotoxicity in an Iron Deficiency Rat Model

Table 2

Anaemia and iron status according to iron diet, DOX treatment, and supplementation with FCM.

	Group
	1	2	3	4	5	6	7	8
Treatment
Iron diet	LID	LID	LID	LID	LID	LID	ND	ND
DOX (4 mg/kg BW)	+	+	+	+	+	−	−	+
FCM (mg iron/kg BW)	3	3	15	15	−	−	−	15
	Concurrent with DOX	Three days after DOX	Concurrent with DOX	Three days after DOX				Concurrent with DOX
Saline	−	−	−	−	+	+	+	−
Parameter
Hb (g/dL)	14.5±0.5^‡	14.6±0.3^‡	15.6±0.4	15.5±0.6	10.3±0.3^†§	11.0±0.3^†	17.2±0.7^∗	17.0±0.7^∗
Serum iron (μg/dL)	214.3±17.7	218.7±15.8	221.8±16.0	223.6±15.0	117.1±14.0^†	121.0±15.4	248.6±16.6^∗‖	320.4±19.5^∗¶
TSAT (%)	36.2±2.1	36.3±2.3	36.2±2.0	36.4±2.1	19.2±3.1^†	20.0±3.2	41.3±2.1^∗‖	47.8±2.4^∗¶
L-Ferritin (%/area)	10.3±1.6	10.5±1.0	10.4±1.1	10.7±1.4	1.8±0.4^†	1.6±0.3^†	3.1±0.5^∗	15.7±1.9^∗

Data presented as mean ± SD. LID: low iron diet; ND: normal diet; DOX: doxorubicin; FCM: ferric carboxymaltose; Hb: hemoglobin; TSAT: transferrin saturation.
^∗𝑃<0.05 for G7 and G8 versus G1, G2, G3, G4, G5, and G6; ^†𝑃<0.01 for G5 and G6 versus G1, G2, G3, and G4; ^‡𝑃<0.05 for G1 and G2 versus G3 and G4; ^§𝑃<0.01 for G5 versus G6; ^‖𝑃<0.05 for G7 versus G1, G2, G3, and G4; ^¶𝑃<0.01 for G8 versus G1, G2, G3, G4, and G7.