Table of Contents
Chemotherapy Research and Practice
Volume 2015 (2015), Article ID 197871, 4 pages
http://dx.doi.org/10.1155/2015/197871
Clinical Study

Postchemotherapy Histopathological Evaluation of Ovarian Carcinoma: A 40-Case Study

1Department of Pathology, GGS Medical College, Faridkot, Punjab 151203, India
2Department of Radiotherapy, GGS Medical College, Faridkot 151203, India

Received 25 September 2014; Revised 11 December 2014; Accepted 5 January 2015

Academic Editor: Paolo Pronzato

Copyright © 2015 Kanwardeep Kaur Tiwana et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Ovarian carcinomas are conventionally treated with primary debulking surgery followed by chemotherapy. Nowadays neoadjuvant chemotherapy followed by surgery is an upcoming treatment modality for ovarian carcinoma. This study highlights the histopathological changes observed after neoadjuvant chemotherapy. Present study is a 40-case study stressing five histological parameters: residual tumour, fibrosis, necrosis, inflammation, and psammoma bodies. All these parameters carry prognostic significance and they are easily reproducible. Fleiss kappa statistics were used to measure intraobserver agreement between pathologists which was found to be substantial to almost perfect with κ ranging between 0.621 and 1.00. This study highlights easily reproducible parameters and their incorporation in histopathology report, thus helping in patient management.