Table of Contents
Chemotherapy Research and Practice
Volume 2015, Article ID 639806, 5 pages
http://dx.doi.org/10.1155/2015/639806
Research Article

Aloe vera Gel: Effective Therapeutic Agent against Multidrug-Resistant Pseudomonas aeruginosa Isolates Recovered from Burn Wound Infections

1Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Science, Tehran 1985717443, Iran
2WHO Collaborating Center for Reference and Research on Rabies, Pasteur Institute of Iran, Tehran 1316943551, Iran
3Department of Medical Laboratory Sciences, School of Paramedicine, Qazvin University of Medical Sciences, Qazvin 1651135779, Iran
4Department of Medical Mycology, Pasteur Institute of Iran, Tehran 1316943551, Iran
5Department of Medical Laboratory Sciences, School of Paramedicine, Shahid Beheshti University of Medical Sciences, Tehran 1985717443, Iran

Received 7 May 2015; Revised 28 June 2015; Accepted 12 July 2015

Academic Editor: Athanassios Tsakris

Copyright © 2015 Mehdi Goudarzi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. Japoni, S. Farshad, and A. Alborzi, “Pseudomonas aeruginosa: burn infection, treatment and antibacterial resistance,” Iranian Red Crescent Medical Journal, vol. 11, no. 3, pp. 244–253, 2009. View at Google Scholar · View at Scopus
  2. A. A. El Solh and A. Alhajhusain, “Update on the treatment of Pseudomonas aeruginosa pneumonia,” Journal of Antimicrobial Chemotherapy, vol. 64, no. 2, Article ID dkp201, pp. 229–238, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. J. A. Driscoll, S. L. Brody, and M. H. Kollef, “The epidemiology, pathogenesis and treatment of Pseudomonas aeruginosa infections,” Drugs, vol. 67, no. 3, pp. 351–368, 2007. View at Publisher · View at Google Scholar · View at Scopus
  4. J.-I. Sekiguchi, T. Asagi, T. Miyoshi-Akiyama et al., “Outbreaks of multidrug-resistant Pseudomonas aeruginosa in community hospitals in Japan,” Journal of Clinical Microbiology, vol. 45, no. 3, pp. 979–989, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. O. Lomovskaya, M. S. Warren, A. Lee et al., “Identification and characterization of inhibitors of multidrug resistance efflux pumps in Pseudomonas aeruginosa: novel agents for combination therapy,” Antimicrobial Agents and Chemotherapy, vol. 45, no. 1, pp. 105–116, 2001. View at Publisher · View at Google Scholar · View at Scopus
  6. J. Chen, Z. Su, Y. Liu et al., “Identification and characterization of class 1 integrons among Pseudomonas aeruginosa isolates from patients in Zhenjiang, China,” International Journal of Infectious Diseases, vol. 13, no. 6, pp. 717–721, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. O. Akerele, “WHO guidelines for the assessment of herbal medicines,” Fitoterapia, vol. 63, no. 2, pp. 99–104, 1992. View at Google Scholar · View at Scopus
  8. K. Oluyemisi Folashade, E. Henry Omoregie, and A. Peter Ochogu, “Standardization of herbal medicines—a review,” International Journal of Biodiversity and Conservation, vol. 4, no. 3, pp. 101–112, 2012. View at Google Scholar
  9. S. Thiruppathi, V. Ramasubramanian, T. Sivakumar, and V. Thirumalai Arasu, “Antimicrobial activity of Aloe vera (L.) Burm. f. against pathogenic microorganisms,” The Journal of Biosciences Research, vol. 1, no. 4, pp. 251–258, 2010. View at Google Scholar
  10. A. Surjushe, R. Vasani, and D. Saple, “Aloe vera: a short review,” Indian Journal of Dermatology, vol. 53, no. 4, pp. 163–166, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. F. Nejatzadeh-Barandozi, “Antibacterial activities and antioxidant capacity of Aloe vera,” Organic and Medicinal Chemistry Letters, vol. 3, no. 5, pp. 1–8, 2013. View at Publisher · View at Google Scholar
  12. S. A. Hashemi, S. A. Madani, and S. Abediankenari, “The review on properties of Aloe Vera in healing of cutaneous wounds,” BioMed Research International, vol. 2015, Article ID 714216, 6 pages, 2015. View at Publisher · View at Google Scholar
  13. T. Reynolds and A. C. Dweck, “Aloe vera leaf gel: a review update,” Journal of Ethnopharmacology, vol. 68, no. 1–3, pp. 3–37, 1999. View at Publisher · View at Google Scholar · View at Scopus
  14. S. Satish, D. C. Mohana, M. P. Ranhavendra et al., “Antifungal activity of some plant extracts against important seed borne pathogens of Aspergillus sp.,” International Journal of Agricultural Technology, vol. 3, no. 1, pp. 109–119, 2007. View at Google Scholar
  15. Clinical and Laboratory Standards Institute, Performance Standards for Antimicrobial Susceptibility Testing: Twenty Second Informational Supplement, M100-S20, CLSI, Wayne, Pa, USA, 2012.
  16. W. C. Winn and E. W. Koneman, Koneman's Color Atlas and Textbook of Diagnostic Microbiology, Lippincott Williams & Wilkins, 2006.
  17. M. Fani and J. Kohanteb, “Inhibitory activity of Aloe vera gel on some clinically isolated cariogenic and periodontopathic bacteria,” Journal of Oral Science, vol. 54, no. 1, pp. 15–21, 2012. View at Publisher · View at Google Scholar · View at Scopus
  18. O. Rosca-Casian, M. Parvu, L. Vlase, and M. Tamas, “Antifungal activity of Aloe vera leaves,” Fitoterapia, vol. 78, no. 3, pp. 219–222, 2007. View at Publisher · View at Google Scholar · View at Scopus
  19. Y. Ni, D. Turner, K. M. Yates, and I. Tizard, “Isolation and characterization of structural components of Aloe vera L. leaf pulp,” International Immunopharmacology, vol. 4, no. 14, pp. 1745–1755, 2004. View at Publisher · View at Google Scholar · View at Scopus
  20. T. A. Hema, A. S. Arya, S. Suseelan, R. K. John Celestinal, and P. V. Divya, “Antimicrobial activity of five South Indian medicinal plants against clinical pathogens,” International Journal of Pharma and Bio Sciences, vol. 4, no. 1, pp. 70–80, 2013. View at Google Scholar · View at Scopus
  21. G. S. Prashar P, V. Koul, and S. Sehgal, “In vitro antimicrobial activity of ethanolic extract of Aloe vera against some bacterial and fungal species,” Advanced Biotechnology, vol. 11, no. 3, pp. 32–33, 2011. View at Google Scholar
  22. S. Alemdar and S. Agaoglu, “Investigation of in vitro antimicrobial activity of Aloe vera juice,” Journal of Animal and Veterinary Advances, vol. 8, no. 1, pp. 99–102, 2009. View at Google Scholar · View at Scopus
  23. M. Chinedu Stanley, O. Emmanuel Ifeanyi, and O. Godson Eziokwu, “Antimicrobial effects of Aloe vera on some human pathogens,” International Journal of Current Microbiology and Applied Sciences, vol. 3, no. 3, pp. 1022–1028, 2014. View at Google Scholar
  24. V. G. Manikandan and M. H. Muhammad Ilyas, “Analysis of phytochemical constituents and antibacterial activities of Aloe vera L. against some selected pathogens,” International Journal of Biology, Pharmacy and Allied Sciences, vol. 3, no. 1, pp. 56–62, 2014. View at Google Scholar
  25. S. R. Shilpakala, J. Prathiba, and R. Malathi, “Susceptibilities of Escherichia coli and Staphylococcus aureus to Aloe barbadensis,” European Review for Medical and Pharmacological Sciences, vol. 13, no. 6, pp. 461–464, 2009. View at Google Scholar · View at Scopus
  26. J. M. A. Antonisamy, N. Beaulah, R. Laju et al., “Anti-bacterial and antigungal activity of Aloe vera gel extract,” International Journal of Biomedical and Advance Research, vol. 3, no. 3, pp. 184–187, 2012. View at Google Scholar
  27. O. O. Agarry, M. T. Olaleye, and C. O. Bello-Michael, “Comparative antimicrobial activities of aloe vera gel and leaf,” African Journal of Biotechnology, vol. 4, no. 12, pp. 1413–1414, 2005. View at Google Scholar · View at Scopus
  28. J. N. Anderl, M. J. Franklin, and P. S. Stewart, “Role of antibiotic penetration limitation in Klebsiella pneumoniae biofilm resistance to ampicillin and ciprofloxacin,” Antimicrobial Agents and Chemotherapy, vol. 44, no. 7, pp. 1818–1824, 2010. View at Publisher · View at Google Scholar
  29. S. Manipal, F. Shireen, and D. Prabu, “Anti-fungal activity of Aloe vera: In vitro stud,” SRM Journal of Research in Dental Sciences, vol. 6, no. 2, pp. 92–95, 2015. View at Publisher · View at Google Scholar
  30. G. Kaithwas, A. Kumar, H. Pandey et al., “Investigation of comparative antimicrobial activity of Aloe vera gel and juice,” Pharmacologyonline, vol. 1, pp. 239–243, 2008. View at Google Scholar · View at Scopus
  31. S. Irshad, M. Butt, and H. Younus, “In-vitro antibacterial activity of Aloe barbadensis Miller (Aloe vera),” International Research Journal of Pharmaceuticals, vol. 1, pp. 60–65, 2011. View at Google Scholar
  32. M. Ibrahim, M. Srinivas, and M. Lakshmi Narasu, “Phyto-chemical analysis and antimicrobial evaluation of Aloe vera gel against some human and plant pathogens,” Asian Journal of Current Chemistry, vol. 1, no. 1, pp. 1–11, 2011. View at Google Scholar
  33. R. Pandey and A. Mishra, “Antibacterial activities of crude extract of Aloe barbadensis to clinically isolated bacterial pathogens,” Applied Biochemistry and Biotechnology, vol. 160, no. 5, pp. 1356–1361, 2010. View at Publisher · View at Google Scholar · View at Scopus
  34. S. Subramanian, D. S. Kumar, P. Arulselvan, and G. P. Senthilkumar, “In vitro antibacterial and antifungal activities of ethanolic extract of Aloe vera leaf gel,” Journal of Plant Sciences, vol. 1, no. 4, pp. 348–355, 2006. View at Publisher · View at Google Scholar
  35. M. H. Radha and N. P. Laxmipriya, “Evaluation of biological properties and clinical effectiveness of Aloe vera: a systematic review,” Journal of Traditional and Complementary Medicine, vol. 5, no. 1, pp. 21–26, 2015. View at Publisher · View at Google Scholar
  36. L. Cellini, S. Di Bartolomeo, E. Di Campli, S. Genovese, M. Locatelli, and M. Di Giulio, “In vitro activity of aloe vera inner gel against Helicobacter pylori strains,” Letters in Applied Microbiology, vol. 59, no. 1, pp. 43–48, 2014. View at Publisher · View at Google Scholar · View at Scopus