Comparative Structures and Evolution of Vertebrate Carboxyl Ester Lipase (CEL) Genes and Proteins with a Major Role in Reverse Cholesterol Transport

Figure 7

Phylogenetic tree of vertebrate CEL with human and mouse CES1, CES2, CES3, CES4, and CES5 amino acid sequences. The tree is labeled with the gene name and the name of the vertebrate. Note the major cluster for the vertebrate CEL sequences and the separation of these sequences from human and mouse CES1, CES2, CES3, CES4, and CES5 sequences. The tree is “rooted” with the CES sequence (T27C12) from a nematode (Caenorhabditis elegans). See Table 1 for details of sequences and gene locations. A genetic distance scale is shown (% amino acid substitutions). The number of times a clade (sequences common to a node or branch) occurred in the bootstrap replicates are shown. Only replicate values of 90 or more which are highly significant are shown with 100 bootstrap replicates performed in each case.