APOE and FABP2 Polymorphisms and History of Myocardial Infarction, Stroke, Diabetes, and Gallbladder Disease
Table 4
Odds ratios (ORs) and 95% confidence intervals (CIs) for past history of selected chronic diseases according APOE genotypes and gender.
Diseases
Genotype
Females
Males
P values for interaction
Yes/No
OR
95% CI
Yes/No
OR
95% CI
Myocardial infarction
E2
4/129
0.52
0.17–1.62
12/94
1.70
0.81–3.56
E3
22/475
1.00
—
29/335
1.00
—
E4
21/205
1.93
1.00–3.70
22/144
1.92
1.03–3.58
E4 versus E2E3
2.18
1.16–4.09
1.68
0.94–3.00
0.008
Stroke
E2
9/124
1.34
0.57–3.15
6/100
1.22
0.42–3.55
E3
21/476
1.00
—
16/348
1.00
—
E4
13/213
1.11
0.53–2.33
9/157
1.05
0.42–2.61
E4 versus E2E3
1.03
0.51–2.06
1.00
0.42–2.38
0.850
Diabetes
E2
22/111
0.99
0.56–1.73
14/92
0.93
0.47–1.87
E3
68/429
1.00
—
53/311
1.00
—
E4
32/194
0.89
0.55–1.44
15/151
0.50
0.26–0.97
E4 versus E2E3
0.89
0.56–1.42
0.51
0.27–0.97
0.762
Gallbladder disease
E2
31/102
1.28
0.79–2.08
5/101
0.58
0.22–1.58
E3
92/405
1.00
—
29/335
1.00
—
E4
31/195
0.67
0.43–1.06
15/151
1.14
0.58–2.26
E4 versus E2E3
0.64
0.41–0.99
1.27
0.66–2.46
0.088
ORs were adjusted for age, race, educational levels, cigarette smoking (pack-years), alcohol intake, body mass index, energy-adjusted dietary saturated fat, cholesterol, fiber and total calcium intakes, and family size. E2 includes E2/E2, E2/E3, and E2/E4, and E4 includes E4/E3 and E4/E4. P values for a linear trend for E2, E3 and E4.
