Low-Fat Nondairy Minidrink Containing Plant Stanol Ester Effectively Reduces LDL Cholesterol in Subjects with Mild to Moderate Hypercholesterolemia as Part of a Western Diet

Table 1

Clinical variables during the study.

	Control group (𝑛=29)		STAEST group (𝑛=27)		𝑃^a
	Baseline	Intervention	Baseline	Intervention
N (M/W)	7/22		4/23		0.506^b
Age (y)	54.2±1.8		55.3±1.6		0.837^b
Weight (kg)	70.1±1.8	70.0±1.8	66.3±1.8	66.0±1.8	0.696
BMI (kg/m^2)	24.5±0.5	24.5±0.5	23.7±0.5	23.6±0.5	0.696
Blood leukocytes (10^9/L)^c	5.10±0.26	4.64±0.25	5.26±0.20	4.99±0.21	0.681
Blood erythrocytes (10^12/L)^c	4.70±0.07	4.59±0.07	4.54±0.07	4.48±0.06	0.841
Hemoglobin (g/L)^c	140.4±2.1	138.2±1.9	137.7±1.9	136.3±1.9	0.635
Hematocrit (%)^c	0.42±0.01	0.41±0.0	0.41±0.01	0.40±0.0	0.453
MCV (fl)	88.9±0.7	89.1±0.8	90.3±0.8	89.5±0.8	0.188
MCH (pg)^c	29.9±0.3	30.2±0.3	30.3±0.3	30.5±0.3	0.914
MCHC (g/L)^c	336.9±1.6	338.9±1.7	336.1±1.5	340.5±1.8	0.301
Blood thrombocytes (10^9/L)	255.4±6.9	257.7±7.7	268.0±10.6	258.0±9.0	0.075
ALT(𝜇kat/L)	0.46±0.05	0.47±0.06	0.45±0.03	0.46±0.04	0.800
GGT (U/L)	0.42±0.05	0.41±0.04	0.38±0.05	0.41±0.06	0.895
Creatinine (𝜇mol/L)^c	70.8±1.7	68.9±1.9	65.6±1.8^d	64.2±1.8	0.788
Thyroid stimulating hormone (mlE/L)	1.77±0.13	1.72±0.13	1.81±0.17	1.93±0.19	0.098
hs-CRP (mg/L)	1.54±0.34	1.56±0.34	1.42±0.35	1.54±0.40	0.838
Plasma glucose (mmol/L)^c	5.04±0.09	4.83±0.08	5.07±0.10	4.95±0.12	0.573
Serum total cholesterol (mmol/L)^f	6.54±0.16	6.64±0.18	6.49±0.20	6.03±0.14^d,e	<0.001
LDL cholesterol (mmol/L)^f	4.44±0.16	4.54±0.17	4.35±0.18	3.94±0.13^d,e	<0.001
HDL cholesterol (mmol/L)^f	1.59±0.08	1.59±0.08	1.71±0.08	1.67±0.07	0.421
Serum triglycerides (mmol/L)^f	1.14±0.11	1.12±0.10	0.95±0.06	0.93±0.07	0.558
Non-HDL cholesterol (mmol/L)^f	4.95±0.18	5.05±0.19	4.78±0.19	4.36±0.15^d,e	<0.001
Ratio LDL/HDL cholesterol^f	3.02±0.21	3.09±0.21	2.68±0.17	2.50±0.16^d,e	0.003

Values shown are means ± SEM. ALT: alanine aminotransferase; GGT: gamma-glutamyltransferase; hs-CRP: high sensitive C-reactive protein; MCH: mean corpuscular hemoglobin; MCHC: mean corpuscular hemoglobin concentration; MCV: mean corpuscular volume; and STAEST: plant stanol ester.
aGroup by time interaction (repeated measured variance of analysis (general linear model)).
bDifference between the groups: gender (Fisher exact test) and age (univariate analysis of variance (general linear model)).
^c𝑃<0.05, significant change over time.
^d𝑃<0.05 significantly different from control.
^e𝑃<0.05 significantly different from baseline.
fControl (𝑛=29), STAEST (𝑛=26).