Cholesterol

Clinical Study

HDL-C Response Variability to Niacin ER in US Adults

Table 2

Overall HDL effect by niacin ER dose.


Demographics and lipids	500 mg niacin ER dose					1000 mg niacin ER dose					value^b
Demographics and lipids		Baseline HDL-C levels Mean (SD)	Follow-up HDL-C levels Mean (SD)	HDL-C effect Mean (SD)	value^a		Baseline HDL-C levels Mean (SD)	Follow-up HDL-C levels Mean (SD)	HDL-C effect Mean (SD)	value^a

Gender
Males	480	37.1 (0.4)	39.4 (0.4)	0.08 (0.01)	<0.001	120	39.0 (0.9)	41.6 (0.9)	0.08 (0.02)	0.029	0.768^b
Females	200	45.5 (1.1)	49.3 (1.2)	0.10 (0.01)	0.019	34	48.5 (2.6)	57.4 (3.6)	0.19 (0.03)	0.048	0.021^b
value^c		<0.001	<0.001	0.221			0.001	<0.001	0.009		0.053^d
Age (years)
18 to 40	79	37.9 (1.2)	40.0 (1.1)	0.10 (0.04)	0.196	12	38.9 (2.9)	40.4 (1.7)	0.07 (0.05)	0.659	0.660^b
41 to 65	516	39.4 (0.5)	42.2 (0.6)	0.08 (0.01)	<0.001	131	41.3 (1.1)	45.8 (1.3)	0.12 (0.02)	0.008	0.057^b
≥66	85	42.5 (1.4)	45.5 (1.4)	0.08 (0.02)	0.126	11	41.2 (2.2)	41.9 (1.8)	0.03 (0.05)	0.803	0.335^b
value^d		0.032	0.018	0.842			0.799	0.343	0.242		0.613^d
HDL-C mg/dL (both genders)
40	423	32.8 (0.3)	36.3 (0.4)	0.12 (0.01)	<0.001	87	33.5 (0.5)	37.7 (0.8)	0.13 (0.02)	<0.001	0.437^b
≥40	257	50.8 (0.7)	52.3 (0.8)	0.03 (0.01)	0.168	67	50.9 (1.2)	54.7 (1.9)	0.07 (0.02)	0.096	0.094^b
value^c		<0.001	<0.001	<0.001			<0.001	<0.001	0.037		0^d
LDL-C mg/dL
<130	264	39.0 (0.7)	41.3 (0.8)	0.07 (0.01)	0.025	88	40.6 (1.1)	44.9 (1.2)	0.12 (0.02)	0.008	0.160^b
≥130	176	41.8 (0.9)	44.6 (1.0)	0.08 (0.02)	0.031	33	44.7 (2.7)	48.9 (3.5)	0.09 (0.03)	0.344	0.802^b
value^c		0.011	0.006	0.474			0.161	0.291	0.489		0.472^d
TG mg/dL
<150	192	44.0 (1.1)	46.5 (1.1)	0.08 (0.02)	0.102	60	46.6 (1.6)	50.4 (2.2)	0.08 (0.02)	0.166	0.899^b
≥150	483	38.0 (0.4)	40.9 (0.5)	0.08 (0.01)	<0.001	93	37.6 (1.0)	41.8 (1.1)	0.12 (0.02)	0.005	0.060^b
value^c		<0.001	<0.001	0.943			<0.001	0.001	0.111		0.362^d
TC mg/dL
<200	301	36.8 (0.6)	39.5 (0.6)	0.09 (0.01)	0.001	96	39.6 (1.0)	43.7 (1.2)	0.11 (0.02)	0.007	0.362^b
≥200	375	42.2 (0.6)	44.9 (0.7)	0.08 (0.01)	0.004	57	43.7 (1.9)	47.6 (2.4)	0.10 (0.03)	0.200	0.530^b
value^c		<0.001	<0.001	0.259			0.052	0.144	0.549		0.195^d

Definition of lipids: HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; TG: triglycerides; TC: total cholesterol.
^a value tested the null hypothesis that there is no difference in the baseline and follow-up HDL-C levels using the Student’s -test.
^b value tested the null hypotheses that there is no difference in the mean HDL-C effect across niacin ER dose groups using the Student’s -test.
^c value tested the null hypothesis that there is no difference in the mean HDL-C effect across each risk factor/lipid level category using the Student’s -test.
^d value tested the null hypothesis that there is no difference in the mean HDL-C effect across each risk factor/lipid level category using the -statistic.