Mutation pph2_prob Polyphen class RFscore Mutpred hypothesis MAF Deviation A1010V 0,104 neutral 0,816 Loss of ubiquitination at K1009 NA 0,50346003 A1046D 0,999 deleterious 0,938 Loss of MoRF binding NA 0,04313351 A1182T 0,001 neutral 0,425 Loss of sheet 0,00045914 0,29981328 A1407T 0,119 neutral 0,277 Gain of helix 0,00045914 0,11172287 A1631V 0,401 neutral 0,321 Loss of sheet NA 0,05656854 A1670T 0,997 deleterious 0,566 Gain of glycosylation at A1670 NA 0,30476302 A1756T 0,81 deleterious 0,418 Gain of glycosylation at A1756 NA 0,27718586 A2028V 0,146 neutral 0,564 Gain of methylation at K2023 0 0,29557064 A255T 0 neutral 0,755 Loss of helix NA 0,53386562 A343V 0,001 neutral 0,227 Loss of disorder NA 0,15980613 A391S 0,318 neutral 0,34 Gain of disorder NA 0,01555635 A594T 0,02 neutral 0,406 Loss of catalytic residue at A594 NA 0,27294322 A697T 0,416 neutral 0,508 Gain of sheet 0,00045914 0,06505382 A746G 1 deleterious 0,608 Loss of stability 0,00045914 0,27718586 A779T 0,411 neutral 0,468 Loss of helix NA 0,04030509 A795S 0,07 neutral 0,494 Loss of helix NA 0,29981328 A937V 0,991 deleterious 0,921 Loss of disorder NA 0,04949748 C1477F 1 deleterious 0,496 Loss of catalytic residue at C1477 NA 0,35638182 C1477R 1 deleterious 0,852 Gain of methylation at C1477 NA 0,10465181 C1660R 0,954 deleterious 0,917 Gain of methylation at C1660 NA 0,02616295 C3S 0,005 neutral 0,48 Gain of disorder NA 0,33587572 C887F 0,002 neutral 0,604 Gain of phosphorylation at S884 0,00137741 0,42567828 D1018G 0,992 deleterious 0,535 Loss of catalytic residue at D1018 NA 0,3231478 D1099N 1 deleterious 0,906 Gain of sheet NA 0,06646804 D1099Y 1 deleterious 0,946 Loss of disorder NA 0,03818377 D1263E 0,003 neutral 0,214 Gain of helix NA 0,14919953 D1289N 0,339 neutral 0,573 Gain of sheet NA 0,16546299 D1553E 0,001 neutral 0,273 Loss of helix NA 0,19233304 D1706N 1 deleterious 0,611 Loss of helix NA 0,27506454 D2243E 0,078 neutral 0,491 Gain of relative solvent accessibility 0,00459137 0,2920351 D434E 0,005 neutral 0,413 Gain of disorder NA 0,28849957 D441N 0 neutral 0,348 Loss of helix NA 0,24607316 D444E 0 neutral 0,338 Loss of helix NA 0,23900209 D446E 0 neutral 0,301 Loss of helix NA 0,21283914 D457E 0,001 neutral 0,566 Loss of helix NA 0,39951533 D462G 0,071 neutral 0,555 Loss of catalytic residue at D462 NA 0,34223968 D581E 0,38 neutral 0,346 Loss of helix NA 0,02404163 D677E 0,158 neutral 0,846 Loss of loop NA 0,48648947 D831N 0,999 deleterious 0,589 Gain of helix NA 0,28991378 D917N 0,1 neutral 0,577 Gain of MoRF binding NA 0,33728994 E1005K 0,026 neutral 0,542 Gain of MoRF binding NA 0,3648671 E1172D 0,003 neutral 0,253 Loss of sheet 0,0509642 0,1767767 E1172G 0,003 neutral 0,281 Loss of sheet 0,00091827 0,19657569 E1253K 0,048 neutral 0,453 Gain of ubiquitination at E1253 NA 0,28637825 E1916A 0,027 neutral 0,34 Gain of MoRF binding 0,00183655 0,22132442 E226G 0,019 neutral 0,47 Loss of stability NA 0,31890516 E284K 0,206 neutral 0,842 Gain of methylation at E284 NA 0,44971991 E815G 0,072 neutral 0,361 Loss of disorder NA 0,20435386 E868K 0,051 neutral 0,69 Gain of methylation at E868 0,00275482 0,45184123 F1285L 0,001 neutral 0,235 Loss of loop NA 0,16546299 F1573S 0,065 neutral 0,532 Gain of disorder NA 0,33021887 F2009S 0,811 deleterious 0,932 Gain of disorder NA 0,08555992 F2082V 0,266 neutral 0,442 Gain of MoRF binding NA 0,12445079 F2163S 0,939 deleterious 0,727 Loss of sheet NA 0,14990664 F346L 0 neutral 0,239 Gain of disorder NA 0,16899852 F426L 0,94 deleterious 0,549 Gain of helix 0,00045914 0,27647875 F632C 0,998 deleterious 0,694 Loss of stability 0,00045914 0,21496046 F950S 0,995 deleterious 0,664 Gain of disorder NA 0,23405235 G1049R 1 deleterious 0,638 Gain of MoRF binding NA 0,25597266 G1216V 0,951 deleterious 0,844 Loss of ubiquitination at K1214 NA 0,07566043 G1321A 0,936 deleterious 0,715 Gain of catalytic residue at G1321 NA 0,15627061 G156V 0,017 neutral 0,389 Loss of helix NA 0,26304372 G2147E 0,49 neutral 0,397 Loss of catalytic residue at S2148 NA 0,06576093 G315W 0,997 deleterious 0,526 Loss of disorder NA 0,33304729 G616V 0,998 deleterious 0,444 Loss of disorder NA 0,39173716 G788W 1 deleterious 0,664 Loss of catalytic residue at P784 NA 0,23758788 G851R 0,998 deleterious 0,71 Gain of catalytic residue at G851 NA 0,20364675 H263D 0 neutral 0,399 Loss of helix NA 0,28213561 H551D 0,613 deleterious 0,468 Gain of sheet NA 0,10253048 I1084V 0,241 neutral 0,511 Gain of MoRF binding NA 0,19091883 I1239V 0,078 neutral 0,376 Loss of catalytic residue at L1244 NA 0,21071782 I1517R 0,962 deleterious 0,917 Gain of catalytic residue at I1517 NA 0,03181981 I1555T 0,439 neutral 0,484 Loss of stability NA 0,03181981 I1911T 0,006 neutral 0,437 Loss of stability 0,00045914 0,30476302 I35V 0,066 neutral 0,31 Loss of helix 0,00045914 0,17253406 I546V 0 neutral 0,31 Gain of MoRF binding NA 0,2192031 I560T 0,829 deleterious 0,496 Loss of stability NA 0,23546656 I649F 0,97 deleterious 0,669 Loss of catalytic residue at I649 NA 0,21283914 I659V 0,034 neutral 0,405 Loss of methylation at K663 NA 0,26233662 I883M 0,002 neutral 0,296 Gain of disorder 0,365473 0,20788939 K1250R 0,118 neutral 0,377 Loss of methylation at K1250 0,00045914 0,18314066 K1587R 0,034 neutral 0,377 Gain of helix 0,410927 0,24253763 K166R 0 neutral 0,251 Loss of ubiquitination at K166 NA 0,1774838 K1761T 0,038 neutral 0,545 Loss of methylation at K1761 0,00045914 0,35850314 K1974R 0,158 neutral 0,679 Loss of ubiquitination at K1974 NA 0,36840263 K2040E 0,243 neutral 0,459 Loss of MoRF binding 0,00045914 0,15273507 K401Q 0,007 neutral 0,322 Loss of ubiquitination at K401 NA 0,22273864 K613E 0,002 neutral 0,428 Loss of ubiquitination at K613 0,00045914 0,30122749 K776N 0,985 deleterious 0,568 Loss of methylation at K776 0,00183655 0,29486353 L1041V 0,999 deleterious 0,625 Loss of ubiquitination at K1040 0,00137741 0,26445794 L1379F 0,987 deleterious 0,866 Loss of catalytic residue at L1379 NA 0,08555992 L1408F 0,443 neutral 0,418 Loss of stability 0,00045914 0,01767767 L1648P 0,961 deleterious 0,749 Loss of stability NA 0,14990664 L184S 0,007 neutral 0,576 Loss of sheet 0,00045914 0,40234376 L184W 0,928 deleterious 0,54 Gain of helix 0,00045914 0,27435743 L2032M 0,897 deleterious 0,688 Gain of methylation at K2036 NA 0,14778532 L2168P 0,984 deleterious 0,693 Gain of disorder NA 0,20576807 L2187Q 0,995 deleterious 0,698 Gain of disorder 0,00045914 0,21001071 M1012I 0,008 neutral 0,595 Loss of catalytic residue at V1008 NA 0,41507168 M1091T 0,98 deleterious 0,955 Gain of disorder NA 0,01767767 M233V 0 neutral 0,417 Loss of stability NA 0,29486353 M415L 0,002 neutral 0,423 Gain of relative solvent accessibility NA 0,29769196 M674L 0,534 deleterious 0,599 Loss of catalytic residue at M674 0,00045914 0,04596194 N1185K 0,01 neutral 0,583 Gain of MoRF binding NA 0,40517219 N1185S 0,002 neutral 0,358 Gain of helix NA 0,25173001 N1406K 0,006 neutral 0,408 Gain of ubiquitination at N1406 NA 0,28425693 N1611D 0,968 deleterious 0,921 Loss of MoRF binding NA 0,03323402 N1800H 0,758 deleterious 0,826 Loss of stability NA 0,04808326 N1800S 0,241 neutral 0,84 Loss of stability NA 0,42355696 N2119Y 0,96 deleterious 0,727 Loss of MoRF binding NA 0,16475588 N820S 0,001 neutral 0,348 Loss of catalytic residue at N820 NA 0,24536605 N935H 0,996 deleterious 0,966 Gain of disorder NA 0,02121321 N935S 0,831 deleterious 0,969 Gain of disorder NA 0,09758074 P1065S 0,998 deleterious 0,906 Gain of MoRF binding NA 0,06505382 P1475S 1 deleterious 0,235 Gain of phosphorylation at P1475 NA 0,54093669 P1878T 0,019 neutral 0,482 Gain of helix NA 0,32739044 P2150L 0,068 neutral 0,826 Loss of disorder NA 0,53598694 P248A 0 neutral 0,207 Loss of helix NA 0,1463711 P250L 0 neutral 0,244 Loss of glycosylation at P250 NA 0,17253406 P641L 1 deleterious 0,603 Gain of MoRF binding NA 0,28072139 P855S 0,97 deleterious 0,59 Loss of catalytic residue at W856 NA 0,26870058 P85L 0,394 neutral 0,618 Loss of disorder 0,00045914 0,15839192 Q1279K 0,032 neutral 0,715 Gain of MoRF binding NA 0,48295393 Q188K 0,001 neutral 0,543 Gain of ubiquitination at Q188 0 0,38325188 Q205E 0,01 neutral 0,255 Loss of loop NA 0,17324116 Q205R 0 neutral 0,279 Gain of helix NA 0,19728279 Q2196H 0,011 neutral 0,798 Loss of MoRF binding NA 0,55649304 Q2210H 0,984 deleterious 0,388 Gain of catalytic residue at D2214 NA 0,42143564 Q597R 1 deleterious 0,71 Gain of MoRF binding NA 0,20506097 Q849R 0,689 deleterious 0,662 Gain of methylation at Q849 NA 0,01909188 R104C 0,985 deleterious 0,589 Loss of MoRF binding NA 0,28001429 R1068C 1 deleterious 0,962 Loss of MoRF binding NA 0,02687006 R1068H 1 deleterious 0,972 Loss of MoRF binding NA 0,01979899 R1082C 1 deleterious 0,694 Loss of MoRF binding NA 0,21637468 R1195Q 0,044 neutral 0,364 Loss of loop NA 0,22627417 R1195W 0,952 deleterious 0,589 Gain of catalytic residue at A1194 NA 0,25667976 R126H 0 neutral 0,467 Loss of MoRF binding NA 0,33021887 R1273L 0,007 neutral 0,35 Loss of loop NA 0,24253763 R1283C 0,001 neutral 0,449 Gain of ubiquitination at K1278 NA 0,31678384 R1341T 0,016 neutral 0,604 Loss of methylation at R1341 0,41577879 R1344W 0,993 deleterious 0,64 Loss of methylation at K1345 0,00045914 0,24960869 R1417H 0,837 deleterious 0,457 Loss of phosphorylation at T1416 0,00183655 0,26870058 R1615P 0,947 deleterious 0,895 Loss of methylation at R1615 0,03676955 R1615Q 0,187 neutral 0,679 Gain of helix NA 0,34789654 R1680Q 0,997 deleterious 0,807 Gain of ubiquitination at K1683 NA 0,13435029 R1680W 1 deleterious 0,911 Loss of disorder NA 0,06293251 R1839H 0,006 neutral 0,48 Loss of phosphorylation at S1842 0,00045914 0,33516861 R1851Q 0,015 neutral 0,897 Gain of catalytic residue at R1851 NA 0,62366818 R1897W 0,009 neutral 0,408 Probably damaging NA 0,28213561 R1901S 0,091 neutral 0,81 Gain of phosphorylation at R1901 NA 0,50840978 R1925Q 0,006 neutral 0,69 Loss of MoRF binding 0,00229568 0,48366104 R2004K 0,911 deleterious 0,699 Gain of ubiquitination at R2004 NA 0,14990664 R2030Q 0,032 neutral 0,442 Loss of MoRF binding NA 0,28991378 R2081W 0,998 deleterious 0,936 Loss of MoRF binding NA 0,04384062 R2173Q 0,008 neutral 0,382 Gain of sheet NA 0,26445794 R2189G 0,142 neutral 0,443 Loss of MoRF binding NA 0,21283914 R219K 0 neutral 0,41 Gain of ubiquitination at R219 0,419192 0,28991378 R230C 0 neutral 0,68 Loss of MoRF binding 0,00734619 0,48083261 R306G 0,04 neutral 0,463 Loss of helix 0,29910617 R306H 0,899 deleterious 0,431 Loss of helix NA 0,33092597 R369H 0,937 deleterious 0,433 Loss of MoRF binding NA 0,35638182 R437Q 0,088 neutral 0,48 Loss of helix NA 0,27718586 R437W 0,991 deleterious 0,562 Gain of catalytic residue at L435 NA 0,30334881 R443K 0 neutral 0,44 Loss of stability 0,00045914 0,31112698 R496W 0,209 neutral 0,576 Loss of loop NA 0,25950819 R500H 0,013 neutral 0,519 Loss of helix NA 0,35779603 R587W 1 deleterious 0,688 Loss of disorder NA 0,22061732 R638Q 0,957 deleterious 0,664 Loss of methylation at R638 NA 0,20718229 R638W 0,999 deleterious 0,671 Loss of methylation at R638 0,00045914 0,23193102 R666Q 1 deleterious 0,437 Gain of ubiquitination at K668 NA 0,39810112 R666W 1 deleterious 0,56 Gain of catalytic residue at R666 NA 0,31112698 R672Q 0,832 deleterious 0,501 Loss of MoRF binding NA 0,23405235 R965C 0,302 neutral 0,608 Loss of disorder 0,21637468 R999C 0,127 neutral 0,766 Loss of solvent accessibility NA 0,45184123 R999L 0,208 neutral 0,748 Loss of solvent accessibility NA 0,38183766 S107A 0,002 neutral 0,342 Gain of helix NA 0,24041631 S1141Y 0,805 deleterious 0,306 Loss of phosphorylation at S1141 NA 0,35284628 S1157N 0,022 neutral 0,355 Gain of sheet 0,00045914 0,23546656 S116N 0,196 neutral 0,241 Loss of phosphorylation at S116 NA 0,03181981 S1181F 0,042 neutral 0,542 Loss of disorder 0,00045914 0,35355339 S1255R 0,027 neutral 0,326 Loss of glicosilation at S1255 0,00183655 0,21142493 S1280R 0,009 neutral 0,351 Gain of sheet 0,00045914 0,24183052 S1376G 0,007 neutral 0,407 Gain of methylation at K1373 0,28284271 S139G 0 neutral 0,284 Gain of helix NA 0,20081833 S1506L 0,996 deleterious 0,733 Loss of helix NA 0,18596908 S1536F 0,998 deleterious 0,594 Loss of disorder NA 0,28567114 S1731C 0,893 deleterious 0,526 Loss of helix 0,25950819 S212T 0,028 neutral 0,375 Gain of helix 0,00459137 0,24536605 S2182F 0,578 deleterious 0,498 Loss of disorder NA 0,05656854 S2186F 0,862 deleterious 0,458 Loss of disorder NA 0,28567114 S442R 0,001 neutral 0,449 Loss of helix NA 0,31678384 S713G 1 deleterious 0,576 Loss of stability NA 0,29981328 S780N 0,996 deleterious 0,559 Loss of stability NA 0,30900566 T1175M 0,432 neutral 0,331 Loss of sheet 0,00091827 0,07141779 T1242M 0,993 deleterious 0,62 Loss of catalytic residue at T1242 NA 0,26375083 T1399M 0,003 neutral 0,279 Loss of glycosylation at T1399 NA 0,19516147 T1401I 0,003 neutral 0,368 Loss of glycosylation at T1401 NA 0,25809398 T1427M 0,005 neutral 0,352 Gain of catalytic residue at T1427 0,00091827 0,24536605 T2073A 0,852 deleterious 0,657 Loss of phosphorylation at T2073 0,13788582 T459P 0,03 neutral 0,534 Gain of helix 0,35638182 T515A 0,04 neutral 0,449 Gain of helix NA 0,28920667 T774P 0,003 neutral 0,61 Gain of methylation at K776 0,00183655 0,42921382 T929I 0,946 deleterious 0,889 Loss of disorder NA 0,04030509 T940M 1 deleterious 0,844 Loss of methylation at K939 NA 0,11030866 V1054I 0,951 deleterious 0,51 Loss of ubiquitination at K1052 NA 0,31183409 V1096I 0 neutral 0,467 Gain of helix NA 0,33021887 V1158I 0,065 neutral 0,226 Loss of sheet NA 0,11384419 V1674I 0,053 neutral 0,376 Loss of catalytic residue at V1674 0,00137741 0,22839549 V1704D 0,752 deleterious 0,876 Loss of helix NA 0,08768124 V1806M 0,98 deleterious 0,417 Gain of ubiquitination at K1804 NA 0,39810112 V1858M 0,305 neutral 0,472 Loss of catalytic residue at V1858 NA 0,11808683 V2035M 0,042 neutral 0,38 Loss of methylation at K2036 NA 0,23900209 V2244I 0,002 neutral 0,386 Gain of sheet NA 0,271529 V304M 0,823 deleterious 0,387 Gain of disorder NA 0,30829856 V380I 0,001 neutral 0,353 Gain of methylation at K376 NA 0,24890159 V399A 0,071 neutral 0,563 Gain of disorder 0,00183655 0,34789654 V408G 0,101 neutral 0,431 Loss of stability NA 0,23334524 V481L 0,001 neutral 0,374 Gain of sheet 0,00045914 0,26375083 V589I 0,004 neutral 0,334 Gain of catalytic residue at V589 0,00091827 0,23334524 V654G 0,433 neutral 0,438 Loss of stability NA 0,00353553 V702A 0,002 neutral 0,408 Loss of stability NA 0,28708535 V724M 0,833 deleterious 0,462 Loss of catalytic residue at V724 0,00045914 0,26233662 V771M 0,034 neutral 0,421 Loss of ubiquitination at K776 0,0606061 0,27365032 V825I 0,001 neutral 0,401 Loss of catalytic residue at V825 0,128099 0,28284271 W1699C 1 deleterious 0,915 Gain of catalytic residue at L1700 NA 0,06010408 W590L 0,841 deleterious 0,888 Loss of helix 0,03323402 W590S 0,889 deleterious 0,857 Gain of disorder 0,02262742 W840R 0,998 deleterious 0,923 Gain of methylation at W840 NA 0,05303301 Y1921H 0,986 deleterious 0,752 Gain of disorder NA 0,16546299 Y2178H 0,982 deleterious 0,826 Gain of disorder NA 0,11030866 Y2206D 0,992 deleterious 0,878 Gain of sheet NA 0,08061017 Y482C 0,03 neutral 0,826 Gain of loop NA 0,56285691 Y835H 0,967 deleterious 0,653 Loss of stability NA 0,22203153
