The Influence of an Obesogenic Diet on Oxysterol Metabolism in C57BL/6J Mice

Table 2

The effects of the high fat/high cholesterol diet on fasting lipoprotein lipid composition.

Variables	VLDL		LDL		LDL/HDL1		HDL
	ND	HFC	ND	HFC	ND	HFC	ND	HFC
Cholesterol; (mg/dL)	0.79±0.41	6.36±1.84^†	1.24±0.14	4.29±2.32^∗	1.39±0.56	9.42±7.26	17.56±5.05	38.04±11.60^∗
Triglyceride; (mg/dL)	0.89±0.84	1.66±0.95	0.24±0.14	2.52±1.71^∗	0.31±0.21	4.43±3.15^∗	8.70±2.11	18.41±5.82^∗
Phospholipid; (mg/dL)	1.19±0.84	1.58±0.95	0.42±0.14	1.93±0.92^∗	0.39±0.31	3.90±2.78^∗	19.78±7.04	39.06±14.53^∗
Protein; (mg/dL)	5.10±0.86	2.62±0.70^†	2.30±1.16	3.52±1.27	1.91±0.92	5.93±2.62^∗	46.43±10.76	43.73±9.24
Cholesterol; (µg/µg protein)	0.19±0.06	2.41±0.30^‡	0.98±1.14	1.15±0.23	1.12±1.07	1.42±0.48^∗	0.38±0.04	0.86±0.12^‡
Triglyceride; (µg/µg protein)	0.23±0.17	0.60±0.32	0.16±0.16	0.64±0.30^∗	0.32±0.45	0.67±0.24	0.19±0.01	0.41±0.09^†
Phospholipid; (µg/µg protein)	0.29±0.10	0.59±0.15^†	0.24±0.16	0.54±0.23^∗	0.25±0.19	0.61±0.15^∗	0.41±0.08	0.87±0.24^∗

Note. Data are presented as mean ± SD. ^∗𝑃<0.05, ^†𝑃<0.01, and ^‡𝑃<0.001 significantly different than control group. 𝑛=6 per group. HFC: high fat/high cholesterol diet group; VLDL: very-low density lipoprotein; LDL: low-density lipoprotein; sdLDL/HDL₁: small, dense low-density lipoprotein/high-density lipoprotein-1; HDL: high-density lipoprotein.