Dysfunctional High-Density Lipoprotein: An Innovative Target for Proteomics and Lipidomics

Figure 2

Key molecular checkpoints in HDL dysfunction. Genetic mutations, proinflammatory states, and the acute phase response are the main triggers for HDL dysfunction. For details, see the text. FC: free cholesterol; PL: phospholipids; ABCA-1: ATP-binding cassette transporter A-1; LCAT: Lecithin-Cholesterol Acyltransferase; PON: Paraoxonase; CETP: cholesteryl ester transfer protein; HDL: High-Density Lipoprotein; SR-B1: Scavenger Receptor B1; SAA: Serum Amyloid A; sPLA₂: Secretory Phospholipase A₂.