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Cholesterol
Volume 2015 (2015), Article ID 353164, 9 pages
http://dx.doi.org/10.1155/2015/353164
Clinical Study

Serum Cholesterol Reduction Efficacy of Biscuits with Added Plant Stanol Ester

1Institute of Nutrition, Mahidol University, Salaya, Nakhon-Pathom 73170, Thailand
2Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand

Received 21 September 2014; Revised 14 January 2015; Accepted 16 February 2015

Academic Editor: Bruce Griffin

Copyright © 2015 Wantanee Kriengsinyos et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults, “Executive summary of the third report of the national cholesterol education program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III),” The Journal of the American Medical Association, vol. 285, no. 19, pp. 2486–2497, 2001. View at Google Scholar
  2. C. Baigent, L. Blackwell, J. Emberson et al., “Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials,” The Lancet, vol. 376, pp. 1670–1681, 2010. View at Google Scholar
  3. W. Aekplakorn, S. Taneepanichskul, P. Kessomboon et al., “Prevalence of dyslipidemia and management in the Thai population, national health examination survey IV, 2009,” Journal of lipids, vol. 2014, Article ID 249584, 13 pages, 2014. View at Publisher · View at Google Scholar
  4. P. Khonputsa, J. L. Veerman, T. Vos et al., “Joint prevalence and control of hypercholesterolemia and hypertension in Thailand: third national health examination survey,” Asia-Pacific Journal of Public Health, vol. 24, no. 1, pp. 185–194, 2012. View at Publisher · View at Google Scholar · View at Scopus
  5. “Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III,” Circulation, vol. 106, no. 25, pp. 3143–3421, 2002. View at Publisher · View at Google Scholar
  6. A. H. Lichtenstein, L. J. Appel, M. Brands et al., “Diet and lifestyle recommendations revision 2006: a scientific statement from the American heart association nutrition committee,” Circulation, vol. 114, no. 1, pp. 82–96, 2006. View at Google Scholar · View at Scopus
  7. M. M. Best, C. H. Duncan, E. J. van Loon, and J. D. Wathen, “Lowering of serum cholesterol by the administration of a plant sterol,” Circulation, vol. 10, no. 2, pp. 201–206, 1954. View at Publisher · View at Google Scholar
  8. E. D. Smet, R. P. Mensink, and J. Plat, “Effects of plant sterols and stanols on intestinal cholesterol metabolism: suggested mechanisms from past to present,” Molecular Nutrition & Food Research, vol. 56, no. 7, pp. 1058–1072, 2012. View at Publisher · View at Google Scholar · View at Scopus
  9. A. M. Lees, H. Y. I. Mok, R. S. Lees, M. A. McCluskey, and S. M. Grundy, “Plant sterols as cholesterol-lowering agents: clinical trials in patients with hypercholesterolemia and studies of sterol balance,” Atherosclerosis, vol. 28, no. 3, pp. 325–338, 1977. View at Publisher · View at Google Scholar · View at Scopus
  10. T. Heinemann, G.-A. Kullak-Ublick, B. Pietruck, and K. von Bergmann, “Mechanisms of action of plant sterols on inhibition of cholesterol absorption,” European Journal of Clinical Pharmacology, vol. 40, supplement 1, pp. S59–S63, 1991. View at Publisher · View at Google Scholar · View at Scopus
  11. H. Gylling and T. A. Miettinen, “Serum cholesterol and cholesterol and lipoprotein metabolism in hypercholesterolaemic NIDDM patients before and during sitostanol ester- margarine treatment,” Diabetologia, vol. 37, no. 8, pp. 773–780, 1994. View at Publisher · View at Google Scholar · View at Scopus
  12. H. Gylling, R. Radhakrishnan, and T. A. Miettinen, “Reduction of serum cholesterol in postmenopausal women with previous myocardial infarction and cholesterol malabsorption induced by dietary sitostanol ester margarine: women and dietary sitostanol,” Circulation, vol. 96, no. 12, pp. 4226–4231, 1997. View at Publisher · View at Google Scholar · View at Scopus
  13. P. J. H. Jones, D. E. MacDougall, F. Ntanios, and C. A. Vanstone, “Dietary phytosterols as cholesterol-lowering agents in humans,” Canadian Journal of Physiology and Pharmacology, vol. 75, no. 3, pp. 217–227, 1997. View at Publisher · View at Google Scholar · View at Scopus
  14. J.-L. Bresson, A. Flynn, M. Heinonen et al., “Scientific Opinion of the Panel on Dietetic Products Nutrition and Allergies on a request from the European Commission and a similar request from France in relation to the authorization procedure for health claims on plant stanols and plant sterols and lowering/reducing blood LDL-cholesterol pursuant to Article 14 of Regulation (EC) No 1924/2006,” The EFSA Journal, vol. 1175, pp. 1–9, 2009. View at Publisher · View at Google Scholar
  15. M. Law, “Plant sterol and stanol margarines and health,” British Medical Journal, vol. 320, no. 7238, pp. 861–864, 2000. View at Publisher · View at Google Scholar · View at Scopus
  16. M. B. Katan, S. M. Grundy, P. Jones, M. Law, T. Miettinen, and R. Paoletti, “Efficacy and safety of plant stanols and sterols in the management of blood cholesterol levels,” Mayo Clinic Proceedings, vol. 78, no. 8, pp. 965–978, 2003. View at Publisher · View at Google Scholar · View at Scopus
  17. K. Musa-Veloso, T. H. Poon, J. A. Elliot, and C. Chung, “A comparison of the LDL-cholesterol lowering efficacy of plant stanols and plant sterols over a continuous dose range: results of a meta-analysis of randomized, placebo-controlled trials,” Prostaglandins, Leukotrienes and Essential Fatty Acids, vol. 85, no. 1, pp. 9–28, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. T. A. Miettinen, P. Puska, H. Gylling, H. Vanhanen, and E. Vartiainen, “Reduction of serum-cholesterol with sitostanol-ester margarine in a mildly hypercholesterolemic population,” The New England Journal of Medicine, vol. 333, no. 20, pp. 1308–1312, 1995. View at Publisher · View at Google Scholar · View at Scopus
  19. J. A. Weststrate and G. W. Meijer, “Plant sterol-enriched margarines and reduction of plasma total- and LDL-cholesterol concentrations in normocholesterolaemic and mildly hypercholesterolaemic subjects,” European Journal of Clinical Nutrition, vol. 52, no. 5, pp. 334–343, 1998. View at Publisher · View at Google Scholar · View at Scopus
  20. M. A. Hallikainen and M. I. J. Uusitupa, “Effects of 2 low-fat stanol ester-containing margarines on serum cholesterol concentrations as part of a low-fat diet in hypercholesterolemic subjects,” The American Journal of Clinical Nutrition, vol. 69, no. 3, pp. 403–410, 1999. View at Google Scholar · View at Scopus
  21. H. F. J. Hendriks, J. A. Weststrate, T. van Vliet, and G. W. Meijer, “Spreads enriched with three different levels of vegetable oil sterols and the degree of cholesterol lowering in normocholesterolaemic and mildly hypercholesterolaemic subjects,” European Journal of Clinical Nutrition, vol. 53, no. 4, pp. 319–327, 1999. View at Publisher · View at Google Scholar · View at Scopus
  22. A. Andersson, B. Karlstrom, R. Mohsen, and B. Vessby, “Cholesterol-lowering effects of a stanol ester-containing low-fat margarine used in conjunction with a strict lipid-lowering diet,” European Heart Journal Supplements, vol. 1, pp. S80–S90, 1999. View at Google Scholar
  23. J. Plat, E. N. M. van Onselen, M. M. A. van Heugten, and R. P. Mensink, “Effects on serum lipids, lipoproteins and fat soluble antioxidant concentrations of consumption frequency of margarines and shortenings enriched with plant stanol esters,” European Journal of Clinical Nutrition, vol. 54, no. 9, pp. 671–677, 2000. View at Publisher · View at Google Scholar · View at Scopus
  24. T. Heinemann, G. A. Kullak-Ublick, B. Pietruck, and K. von Bergmann, “Mechanisms of action of plant sterols on inhibition of cholesterol absorption. Comparison of sitosterol and sitostanol,” European Journal of Clinical Pharmacology, vol. 40, supplement 1, pp. 59–63, 1991. View at Google Scholar
  25. R. P. Mensink, S. Ebbing, M. Lindhout, J. Plat, and M. M. A. van Heugten, “Effects of plant stanol esters supplied in low-fat yoghurt on serum lipids and lipoproteins, non-cholesterol sterols and fat soluble antioxidant concentrations,” Atherosclerosis, vol. 160, no. 1, pp. 205–213, 2002. View at Publisher · View at Google Scholar · View at Scopus
  26. C. A. Spilburg, A. C. Goldberg, J. B. McGill et al., “Fat-free foods supplemented with soy stanol-lecithin powder reduce cholesterol absorption and LDL cholesterol,” Journal of the American Dietetic Association, vol. 103, no. 5, pp. 577–581, 2003. View at Publisher · View at Google Scholar · View at Scopus
  27. W. Kriengsinyos, K. Sumriddetchkajorn, and U. Yamborisut, “Reduction of LDL-cholesterol in mildly hypercholesterolemic Thais with plant stanol ester fortified soy milk,” Journal of the Medical Association of Thailand, vol. 94, no. 11, pp. 1327–1336, 2011. View at Google Scholar · View at Scopus
  28. S. S. AbuMweis, R. Barake, and P. J. H. Jones, “Plant sterols/stanols as cholesterol lowering agents: a meta-analysis of randomized controlled trials,” Food & Nutrition Research, vol. 52, pp. 1–17, 2008. View at Publisher · View at Google Scholar · View at Scopus
  29. T. A. Miettinen, R. S. Tilvis, and Y. A. Kesaniemi, “Serum plant sterols and cholesterol precursors reflect cholesterol absorption and synthesis in volunteers of a randomly selected male population,” American Journal of Epidemiology, vol. 131, no. 1, pp. 20–31, 1990. View at Google Scholar · View at Scopus
  30. National Statistical Office, Report on Health, Welfare and Food Consumption of Thai People Survey, National Statistical Office, 2013.
  31. J. H. Yae, Y. K. Oh, B. K. Joo et al., “Plant stanol esters in low-fat yogurt reduces total and low-density lipoprotein cholesterol and low-density lipoprotein oxidation in normocholesterolemic and mildly hypercholesterolemic subjects,” Nutrition Research, vol. 25, no. 8, pp. 743–753, 2005. View at Publisher · View at Google Scholar · View at Scopus
  32. J. A. Pineda, M. J. C. Ranedo, J. A. Anda, and S. F. Terreros, “Hypocholesteremic effectiveness of a yogurt containing plant stanol esters,” Revista Clínica Española, vol. 205, no. 2, pp. 63–66, 2005. View at Publisher · View at Google Scholar · View at Scopus
  33. N. B. Cater, A.-B. Garcia-Garcia, G. L. Vega, and S. M. Grundy, “Responsiveness of plasma lipids and lipoproteins to plant stanol esters,” The American Journal of Cardiology, vol. 96, no. 1, supplement, pp. 23–28, 2005. View at Publisher · View at Google Scholar · View at Scopus
  34. Ministry of Public Health, The Fourth National Nutirtional Survey of Thailand 1995, Department of Health, Ministry of Public Health, Bangkok, Thailand, 1997.
  35. R. A. DeBose-Boyd, “Feedback regulation of cholesterol synthesis: sterol-accelerated ubiquitination and degradation of HMG CoA reductase,” Cell Research, vol. 18, no. 6, pp. 609–621, 2008. View at Publisher · View at Google Scholar · View at Scopus
  36. E. A. Trautwein, G. S. M. J. E. Duchateau, Y. Lin, S. M. Mel'nikov, H. O. F. Molhuizen, and F. Y. Ntanios, “Proposed mechanisms of cholesterol-lowering action of plant sterols,” European Journal of Lipid Science and Technology, vol. 105, no. 3-4, pp. 171–185, 2003. View at Publisher · View at Google Scholar · View at Scopus
  37. K. von Bergmann, T. Sudhop, and D. Lütjohann, “Cholesterol and plant sterol absorption: recent insights,” The American Journal of Cardiology, vol. 96, no. 1, pp. 10D–14D, 2005. View at Publisher · View at Google Scholar · View at Scopus
  38. I. Ikeda and M. Sugano, “Some aspects of mechanism of inhibition of cholesterol absorption by β-sitosterol,” Biochimica et Biophysica Acta, vol. 732, no. 3, pp. 651–658, 1983. View at Publisher · View at Google Scholar · View at Scopus
  39. M. J. Amiot, D. Knol, N. Cardinault et al., “Phytosterol ester processing in the small intestine: impact on cholesterol availability for absorption and chylomicron cholesterol incorporation in healthy humans,” The Journal of Lipid Research, vol. 52, no. 6, pp. 1256–1264, 2011. View at Publisher · View at Google Scholar · View at Scopus
  40. D. Keszthelyi, D. Knol, F. J. Troost, M. van Avesaat, M. Foltz, and A. A. M. Masclee, “Time of ingestion relative to meal intake determines gastrointestinal responses to a plant sterol-containing yoghurt drink,” European Journal of Nutrition, vol. 52, no. 4, pp. 1417–1420, 2013. View at Publisher · View at Google Scholar · View at Scopus
  41. A. M. E. Doornbos, E. M. Meynen, G. S. M. J. E. Duchateau, H. C. M. van der Knaap, and E. A. Trautwein, “Intake occasion affects the serum cholesterol lowering of a plant sterol-enriched single-dose yoghurt drink in mildly hypercholesterolaemic subjects,” European Journal of Clinical Nutrition, vol. 60, no. 3, pp. 325–333, 2006. View at Publisher · View at Google Scholar · View at Scopus
  42. M. Nissinen, H. Gylling, M. Vuoristo, and T. A. Miettinen, “Micellar distribution of cholesterol and phytosterols after duodenal plant stanol ester infusion,” The American Journal of Physiology—Gastrointestinal and Liver Physiology, vol. 282, no. 6, pp. G1009–G1015, 2002. View at Google Scholar · View at Scopus
  43. E. M. Persson, R. G. Nilsson, G. I. Hansson et al., “A clinical single-pass perfusion investigation of the dynamic in vivo secretory response to a dietary meal in human proximal small intestine,” Pharmaceutical Research, vol. 23, no. 4, pp. 742–751, 2006. View at Publisher · View at Google Scholar · View at Scopus
  44. L. Marciani, E. F. Cox, C. L. Hoad et al., “Effects of various food ingredients on gall bladder emptying,” European Journal of Clinical Nutrition, vol. 67, no. 11, pp. 1182–1187, 2013. View at Publisher · View at Google Scholar · View at Scopus
  45. B. R. Douglas, J. B. M. J. Jansen, R. T. O. T. A. Tham, and C. B. H. W. Lamers, “Coffee stimulation of cholecystokinin release and gallbladder contraction in humans,” The American Journal of Clinical Nutrition, vol. 52, no. 3, pp. 553–556, 1990. View at Google Scholar · View at Scopus
  46. S. Chaiyodsilp, P. Chaiyodsilp, T. Pureekul, R. Srisawas, and Y. Khunaphakdipong, “A prospective randomized trial for reduction on serum low density lipoprotein (LDL) with plant stanol ester mixed in coffee in a hypercholesterolemic Thai population,” The Bangkok Medical Journal, vol. 5, pp. 9–12, 2013. View at Google Scholar
  47. H. Gylling, M. Hallikainen, M. J. Nissinen, and T. A. Miettinen, “The effect of a very high daily plant stanol ester intake on serum lipids, carotenoids, and fat-soluble vitamins,” Clinical Nutrition, vol. 29, no. 1, pp. 112–118, 2010. View at Publisher · View at Google Scholar · View at Scopus