Table 4: HMG-CoA reductase activity, bile acid content, and antioxidant enzyme activities of control and diet-induced hypercholesterolemic rats.

GroupHMG-CoA reductase (nM/mg Pro)Bile acid content (µM/dL)SOD (IU/mg Pro)Catalase (IU/mg Pro)

CON80.0 ± 4.910.442 ± 0.065.21 ± 1.1018.83 ± 4.84
PCN120.0 ± 7.580.650 ± 0.028.07 ± 2.3818.43 ± 1.81
STN62.0 ± 5.600.524 ± 0.065.08 ± 1.4020.41 ± 3.68
MAE-I61.0 ± 4.150.398 ± 0.204.82 ± 1.2519.35 ± 3.58
MAE-II60.15 ± 3.150.351 ± 0.184.61 ± 0.918.5 ± 2.15

CON: control group fed with normal rat chow, PCN: high cholesterol fed positive control group, STN: statin treated high cholesterol fed group, MAE-I: 250 mg kg−1 BW mahagoni aqueous extract treated group, and MAE-II: 500 mg kg−1 BW mahagoni aqueous extract treated group.