In Vivo Antihypercholesterolemic Potential of Swietenia mahagoni Leaf Extract

Table 4

HMG-CoA reductase activity, bile acid content, and antioxidant enzyme activities of control and diet-induced hypercholesterolemic rats.

Group	HMG-CoA reductase (nM/mg Pro)	Bile acid content (µM/dL)	SOD (IU/mg Pro)	Catalase (IU/mg Pro)
CON	80.0 ± 4.91	0.442 ± 0.06	5.21 ± 1.10	18.83 ± 4.84
PCN	120.0 ± 7.58	0.650 ± 0.02	8.07 ± 2.38	18.43 ± 1.81
STN	62.0 ± 5.60	0.524 ± 0.06	5.08 ± 1.40	20.41 ± 3.68
MAE-I	61.0 ± 4.15	0.398 ± 0.20	4.82 ± 1.25	19.35 ± 3.58
MAE-II	60.15 ± 3.15	0.351 ± 0.18	4.61 ± 0.9	18.5 ± 2.15

CON: control group fed with normal rat chow, PCN: high cholesterol fed positive control group, STN: statin treated high cholesterol fed group, MAE-I: 250 mg kg⁻¹ BW mahagoni aqueous extract treated group, and MAE-II: 500 mg kg⁻¹ BW mahagoni aqueous extract treated group.