(a)
(b)
Figure 3: Genome-wide scan for QTL × cross direction interaction for plasma CHO concentrations. (a) Genome-wide LOD score plot. The -axis represents the Chrs and microsatellite marker positions, and the -axis represents the LOD score. The genome-wide threshold LOD scores for a significant QTL × cross direction interaction were 2.4 for autosomes and 3.2 for Chr X, as indicated by horizontal broken line. (b) Allelic contributions of Choldq8, which interacts with cross direction. The -axis shows the genotypes of F2 mice partitioned according to the nearest marker locus genotypes: homozygous DDD alleles are represented by DDD/DDD, homozygous B6 alleles are represented by B6/B6, and heterozygous alleles are represented by DDD/B6. The -axis shows the average CHO concentrations, and the error bars are SEM.