Identification of Quantitative Trait Loci That Determine Plasma Total-Cholesterol and Triglyceride Concentrations in DDD/Sgn and C57BL/6J Inbred Mice

Figure 3

Genome-wide scan for QTL × cross direction interaction for plasma CHO concentrations. (a) Genome-wide LOD score plot. The -axis represents the Chrs and microsatellite marker positions, and the -axis represents the LOD score. The genome-wide threshold LOD scores for a significant QTL × cross direction interaction were 2.4 for autosomes and 3.2 for Chr X, as indicated by horizontal broken line. (b) Allelic contributions of Choldq8, which interacts with cross direction. The -axis shows the genotypes of F₂ mice partitioned according to the nearest marker locus genotypes: homozygous DDD alleles are represented by DDD/DDD, homozygous B6 alleles are represented by B6/B6, and heterozygous alleles are represented by DDD/B6. The -axis shows the average CHO concentrations, and the error bars are SEM.

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