Table 2: Significant and suggestive QTL identified by genome-wide scans of F2 males.

TraitQTLChrPeak cM95% CILODNearest markerHigh strain; inheritanceOverlapping QTL
NameReference

CHOCholdq1180.577.5–85.532.7D1Mit356DDD, AddCq2, Cq6, Hdlq20[6, 8, 12]
323.810.8–56.82.3D3Mit25B6
Choldq4559.817.8–75.82.9D5Mit239DDDHdlq1, Hdlq8 [13]
937.012.0–59.62.2D9Mit207DDD
Choldq61735.117.1–51.13.4D17Mit152B6, AddHdlq29[12]
Choldq7198.03.0–19.05.0D19Mit68DDD, RecHdlq32, Hdlq48[12, 14]

TGTrigdq1184.577.5–93.512.5D1Mit356DDD, DomTgq3 [8]
550.817.8–66.82.6D5Mit239DDD
Trigdq21247.013.0–62.02.9D12Mit259B6Tgq23 [15]
1460.315.3–66.12.3D14Mit165DDD
1553.940.8–53.92.4D15Mit193DDD

QTL, quantitative trait loci; CI, confidence interval; LOD, logarithm of the odds.
Cross direction was included as an additive covariate in all analyses.
QTL symbols, Choldq4 and Trigdq2 were assigned to suggestive QTL on Chrs 5 and 12, respectively, because they were identified as significant QTL if the body weight was included as an additive covariate. Choldq4 was identified as significant QTL in our previous study in female mice [9].
95% CI was defined by a 1.5-LOD decrease.
LOD scores for significant QTL are indicated in bold. For CHO, the threshold LOD scores for significant and suggestive QTL were 3.4 and 2.1, respectively, for autosomes and 2.8 and 1.5, respectively, for Chr X. For TG, the threshold LOD scores for significant and suggestive QTL were 3.5 and 2.1, respectively, for autosomes and 2.8 and 1.5, respectively, for Chr X.
High strain-derived allele was associated with higher plasma lipids.
Mode of inheritance of high strain-derived allele. Dom, dominant; Add, additive; Rec, recessive.