Identification of Quantitative Trait Loci That Determine Plasma Total-Cholesterol and Triglyceride Concentrations in DDD/Sgn and C57BL/6J Inbred Mice

Table 2

Significant and suggestive QTL identified by genome-wide scans of F₂ males.

Trait	QTL	Chr	Peak cM	95% CI	LOD	Nearest marker	High strain; inheritance	Overlapping QTL
								Name	Reference
CHO	Choldq1	1	80.5	77.5–85.5	32.7	D1Mit356	DDD, Add	Cq2, Cq6, Hdlq20	[6, 8, 12]
		3	23.8	10.8–56.8	2.3	D3Mit25	B6
	Choldq4	5	59.8	17.8–75.8	2.9	D5Mit239	DDD	Hdlq1, Hdlq8	[13]
		9	37.0	12.0–59.6	2.2	D9Mit207	DDD
	Choldq6	17	35.1	17.1–51.1	3.4	D17Mit152	B6, Add	Hdlq29	[12]
	Choldq7	19	8.0	3.0–19.0	5.0	D19Mit68	DDD, Rec	Hdlq32, Hdlq48	[12, 14]
TG	Trigdq1	1	84.5	77.5–93.5	12.5	D1Mit356	DDD, Dom	Tgq3	[8]
		5	50.8	17.8–66.8	2.6	D5Mit239	DDD
	Trigdq2	12	47.0	13.0–62.0	2.9	D12Mit259	B6	Tgq23	[15]
		14	60.3	15.3–66.1	2.3	D14Mit165	DDD
		15	53.9	40.8–53.9	2.4	D15Mit193	DDD

QTL, quantitative trait loci; CI, confidence interval; LOD, logarithm of the odds.
Cross direction was included as an additive covariate in all analyses.
QTL symbols, Choldq4 and Trigdq2 were assigned to suggestive QTL on Chrs 5 and 12, respectively, because they were identified as significant QTL if the body weight was included as an additive covariate. Choldq4 was identified as significant QTL in our previous study in female mice [9].
95% CI was defined by a 1.5-LOD decrease.
LOD scores for significant QTL are indicated in bold. For CHO, the threshold LOD scores for significant and suggestive QTL were 3.4 and 2.1, respectively, for autosomes and 2.8 and 1.5, respectively, for Chr X. For TG, the threshold LOD scores for significant and suggestive QTL were 3.5 and 2.1, respectively, for autosomes and 2.8 and 1.5, respectively, for Chr X.
High strain-derived allele was associated with higher plasma lipids.
Mode of inheritance of high strain-derived allele. Dom, dominant; Add, additive; Rec, recessive.