Identification of Quantitative Trait Loci That Determine Plasma Total-Cholesterol and Triglyceride Concentrations in DDD/Sgn and C57BL/6J Inbred Mice

Table 4

Significant and suggestive QTL when D1Mit356 was included as an additive covariate.

Trait	QTL	Chr	Peak cM	95% CI	LOD	Nearest marker	High strain; inheritance	Overlapping QTL
								Name	Reference
CHO	Choldq9	3	19.8	10.8–35.8	4.2	D3Mit25	B6, Add	Cq3	[6]
	Choldq10	4	23.1	9.1–37.1	3.6	D4Mit286	B6, Add	Hdlq10	[16]
	Choldq4	5	59.8	17.8–71.8	3.7	D5Mit239	DDD, Rec	Hdlq1, Hdlq8	[13]
	Choldq2	8	39.0	16.5–51.5	2.8	D8Mit263	B6
	Choldq11	9	37.0	12.0–59.0	4.7	D9Mit207	DDD, Add	Cq4, Cq5, Hdlq17	[6, 7, 17]
	Choldq6	17	37.1	15.1–50.1	5.0	D17Mit152	B6, Rec	Hdlq29	[12]
	Choldq7	19	5.0	3.0–19.0	3.7	D19Mit68	DDD

QTL, quantitative trait loci; CI, confidence interval; LOD, logarithm of the odds.
Cross direction was also included as an additive covariate.
QTL symbols were assigned if they were significant or if they were suggestive but were identified as a significant QTL at least once previously in different genetic crosses.
95% CI was defined by a 1.5-LOD decrease.
LOD scores for significant QTL are indicated in bold. The threshold LOD scores for significant and suggestive QTL were 3.4 and 2.1, respectively, for autosomes and 2.8 and 1.5, respectively, for Chr X.
High strain-derived allele was associated with higher plasma lipids.
Mode of inheritance of high strain-derived allele. Add, additive; Rec, recessive.