Research Article
Identification of Quantitative Trait Loci That Determine Plasma Total-Cholesterol and Triglyceride Concentrations in DDD/Sgn and C57BL/6J Inbred Mice
Table 5
Significant and suggestive QTL for CHO identified by genome-wide scans of combined F2 mice ().
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QTL, quantitative trait loci; CI, confidence interval; LOD, logarithm of the odds. Sex was included as an additive covariate. QTL symbols were assigned if they were significant or if they were suggestive but were identified as significant QTL at least once previously in different genetic crosses [9]. 95% CI was defined by a 1.5-LOD decrease. LOD scores for significant QTL are indicated in bold. The threshold LOD scores for significant and suggestive QTL were 3.5 and 2.1, respectively, for autosomes and 3.7 and 2.1, respectively, for Chr X. High strain-derived allele was associated with higher plasma CHO. |