Table 3: Vascular and Valvular Heart Disease in FH Patients Ranked by Age.

Patient IDAge (years)LDL (mg/dL)GenotypeHomozygousApheresis (years)Previously known CVDIMTVascular diseaseValvular heart disease

496603LDLR C681XYes00.4Plaque
807579LDLR C681XYes00.45
648439LDLRAP Q136XYes00.5
229644LDLR C681XYes20.6
5010565LDLR C681XNo01.45CS, plaque
6110544LDLR C681XYes00.45CS, plaque
7710224LDLR C681XNo00.45
715451LDLR C681XYes90.55mild AS (MG 16, PG 33), ART
1615387LDLRAP Q136XYes20.55
2015500LDLR C681XYes90.6
216455LDLR C681XYes80.55mild AR, mild AS (MG 10, PG 27)
1217558LDLR C681XYes90.5mild AS (MG 11, PG 26), ART
319652LDLR C681XYes110.55Plaquemild AR, mild AS (MG 9, PG 24), mild MR
1419420LDLRAP Q136XYes20.5AoVC
620544LDLR C681XYes122.1Plaquemild AS (MG 16, PG 34), ART
1121649LDLR I451TYes100.5mild AS (MG 19, PG 35), mild MR, ART, AoVC
1524527LDLRAP Q136XYes20.95Plaquemild AS (MG 11, PG 24), ART
825582LDLRAP Q136XNo90.45
2625638LDLR C681XYes71.3CS, plaquemild AR
2327541LDLR C681XYes131.8Plaquemild AR, moderate AS (MG 34, PG 64), AoVC, ART
6728390LDLRAP Q136XYes0MI0.45mild AS, ART
2129495LDLR C681XYes51.05mild AR, ART
7530219LDLR C681XNo10Stroke0.5
2531545LDLR C681XYes82.05CS, plaquemild AR, moderate AS (MG 40, PG 64), mild MR, AoVC, CMV, ART
6631264LDLRAP Q136XYes00.5AoVC
6831245LDLRAP Q136XYes01.5CS, plaquemild MR, AoVC
1732505LDLRAP Q136XYes100.55AOVC
142413LDLR C681XYes9MI, CEA2.1CS, plaquemild AR, moderate AS (MG 40, PG 64), moderate MR, AoVC, ART
3046348LDLR C681XYes60.8CS, plaqueAoVC, ART
2957202LDLR C681XYes16MI0.5Plaquemild AS (MG 20, PG 36), AoVC, ART
7657158LDLR C681XNo7MI, CEA, stroke0.5CSmild AS, AoVC, CMV, ART
1365169LDLR C681XNo10MI, CEA2CS, plaquemild AR, moderate MR, AoVC, CMV, ART

CEA: carotid endarterectomy; MI: myocardial infarction; CS: carotid stenosis; AS: aortic stenosis; ART: aortic root thickening; AR: aortic regurgitation; MR: mitral regurgitation; AoVC: aortic valve calcification; CMV: calcified mitral valve; MG: mean gradient (in mmHg); PG: peak gradient (in mmHg).