Cereal-Based Snack Bar with Added Plant Stanol Ester (Benecol®) Consumed between Meals Lowers Serum Total and LDL Cholesterol Effectively in Mildly to Moderately Hypercholesterolemic Subjects

Table 4

Serum total and lipoprotein lipids¹ during the study in placebo and stanol groups in all completed subjects ().

	Placebo group; ( = 34)	Stanol group; ( = 36)	Mean difference estimate^3	-value
Total cholesterol, mmol/L
Screening	6.18 ± 0.55	6.16 ± 0.62
Baseline	6.13 ± 0.53	6.05 ± 0.72
4 weeks	6.22 ± 0.67	5.71 ± 0.63	−0.507	0.002^4
Change from baseline^2	0.09 ± 0.47	−0.34 ± 0.46	−0.449	<0.001^5
% change from baseline^2	1.6 ± 7.6	−5.2 ± 7.5	−6.806	<0.001^6
LDL cholesterol, mmol/L
Screening	4.26 ± 0.60	4.21 ± 0.61
Baseline	4.17 ± 0.57	4.08 ± 0.71
4 weeks	4.25 ± 0.67	3.79 ± 0.64	−0.459	0.004^4
Change from baseline^2	0.08 ± 0.45	−0.29 ± 0.41	−0.386	<0.001^5
% change from baseline^2	2.2 ± 10.7	−6.4 ± 10.3	−8.622	0.001^6
HDL Cholesterol, mmol/L
Screening	1.79 ± 0.44	1.82 ± 0.45
Baseline	1.75 ± 0.39	1.76 ± 0.45
4 weeks	1.67 ± 0.38	1.67 ± 0.41	0.002	NS^4
Change from baseline^2	−0.07 ± 0.18	−0.09 ± 0.25	−0.011	NS^5
% change from baseline^2	−3.8 ± 9.9	−4.0 ± 13.3	−0.112	NS^6
Triglyceride, mmol/L
Screening	1.18 ± 0.48	1.07 ± 0.43
Baseline	1.17 ± 0.44	1.18 ± 0.53
4 weeks	1.31 ± 0.58	1.20 ± 0.54	−0.104	NS^4
Change from baseline^2	0.14 ± 0.36	0.02 ± 0.35	−0.115	NS^5
% change from baseline^2	13.1 ± 30.5	4.1 ± 26.2	−9.023	NS^6
Non-HDL cholesterol
Screening	4.40 ± 0.63	4.34 ± 0.66
Baseline	4.38 ± 0.59	4.29 ± 0.74
4 weeks	4.55 ± 0.75	4.04 ± 0.69	−0.508	0.004^4
Change from baseline^2	0.17 ± 0.43	−0.25 ± 0.39	−0.426	<0.001^5
% change from baseline^2	3.8 ± 9.6	−5.4 ± 9.4	−9.156	<0.001^6

are means ± SD. To convert cholesterol and triglyceride values to mg/dL, multiply by 38.67 and 88.57 respectively; and percentage change based on individual data, (4 weeks-baseline)/baseline × 100; Difference Estimate between Placebo and Stanol group in change or mean variable; -value for significance of difference between Placebo and Stanol group tested with ANOVA model (equal to independent samples - test); -value for significance of difference between Placebo and Stanol group tested with ANCOVA model adjusted for baseline concentrations; -value for significance of difference between Placebo and Stanol group tested with ANOVA model (equal to independent samples - test).