Programmed Cell Death Induced by Modulated Electrohyperthermia

Figure 2

The summary of possible mechanism of action of programmed cell death can be seen. Based on the immunohistochemistry results, 8 h posttreatment elevated TRAIL-R2 expression was observed, 8–14 h posttreatment mitochondrial cytochrome c release was detected, and in line with this AIF nuclear translocation was revealed on the 14–24 h samples. Between 24–48 h massive DNA fragmentation was identified by TUNEL assay.