Critical Analysis of Electromagnetic Hyperthermia Randomized Trials: Dubious Effect and Multiple Biases

Table 3

Patient characteristic and treatment summary from Jones et al. [12] clinical trial.

Characteristic	No HT (𝑛=52)			HT (𝑛=56)
	Number of Patients		%	Number of Patients		%
Age
Median		59.3	−7 years		52.4
Range		38.4–83.8			18.2–90.9
Sex
Male		13			14
Female		39			42
Site of disease
Breast/chest wall	33		63	37		66
Head and neck	6		12	8		14
Melanoma	6		12	5		9
Other	7		13	6		11
Multiple HT fields	7		13	18		32
Prior XRT	17		33	22		39
RT dose, Gy (given on protocol)
Median		50	+10%		55
Range		18–70			20–70
Metastasis at enrollment	17 of 51		33	16 of 52		31
Additional systemic therapy	34		65	33		59
Hyperthermia dose, CEM 43°C 𝑇90
Median		0.74			14.3
Range		0.07–1.49			0.57–36.21

Abbreviations: HT: hyperthermia; XRT: external radiation therapy; RT: radiation therapy; CEM: cumulative equivalent minutes.