Table of Contents
Conference Papers in Medicine
Volume 2013, Article ID 586769, 4 pages
http://dx.doi.org/10.1155/2013/586769
Conference Paper

Complete Responses after Hyperthermic Ablation by Ultrasound Guided High Intensity Focused Ultrasound Plus Systemic Chemotherapy for Locally Advanced Pancreatic Cancer

1Surgical Oncology HIFU Unit, Hospital Universitari Mutua Terrassa (HUMT), Placa Dr. Robert 5, 08221 Terrassa, Barcelona, Spain
2Pediatric Department, Hospital Universitari Mutua Terrassa (HUMT), Placa Dr. Robert 5, 08221 Terrassa, Barcelona, Spain
3Medical Direction Department, Hospital Universitari Mutua Terrassa (HUMT), Placa Dr. Robert 5, 08221 Terrassa, Barcelona, Spain

Received 14 January 2013; Accepted 3 April 2013

Academic Editors: G. F. Baronzio, M. Jackson, D. Lee, and A. Szasz

This Conference Paper is based on a presentation given by Joan Vidal-Jove at “Conference of the International Clinical Hyperthermia Society 2012” held from 12 October 2012 to 14 October 2012 in Budapest, Hungary.

Copyright © 2013 Joan Vidal-Jove et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We describe results in unresectable pancreatic tumors treated with USgHIFU hyperthermia ablation plus adjuvant chemotherapy. Materials and Methods. Thirty two cases of nonresectable pancreatic tumors were treated from March 2010 to March 2012, and all of them underwent systemic chemotherapy. Clinical responses (thermal ablation achieved) were measured by image techniques. There were 23 stage III cases and 9 stage IV cases. Complications were also analyzed. Results. Clinical responses (ablation obtained) were 82% in all cases, sustained at 8 weeks of the procedure. We obtained 8 complete responses (25%) at the end of the combined treatment, 7 from stage III patients and 1 from stage IV. Major complications included (1) severe pancreatitis with GI bleeding and (2) skin burning grade III that required plastic surgery. No deaths were registered. Median survival was 12.5 month (6 months–2.5 year). Conclusion. HIFU plus SC is a potentially effective and safe modality for the treatment of unresectable pancreatic cancer.