Immune Regulation and Oxidative Stress Reduction by Preimplantation Factor following Syngeneic or Allogeneic Bone Marrow Transplantation

Figure 1

PIF protects against GVHD after semi-/full allogeneic BMT. (a) GVHD score after semi-allogeneic BMT 4 weeks after BMT and (b) 6 weeks after BMT; summary of 4 experiments. (𝑡-test: 𝑃≤0.0001 and 𝑃≤0.004, resp.). (c) Survival of mice from day 0 to day 112 after semi-allogeneic BMT; summary of 2 experiments. (𝜒²: 𝑃≤0.0004). (d) GVHD score 4 weeks after full-allogeneic BMT; summary of 2 experiments. (𝑡-test: 𝑃≤0.01). (e) Representative pictures of recipient mice one month after semi-allogeneic BMT (upper panel). Representative histology of skin (lower panel) and (f) liver two months after semi-allogeneic BMT. (Mann-Whitney: 𝑃≤0.02 and 𝑃≤0.03, resp.). (g) Representative histology of colon 23 days after full-allogeneic BMT.