Table of Contents
Conference Papers in Medicine
Volume 2013, Article ID 827686, 5 pages
http://dx.doi.org/10.1155/2013/827686
Conference Paper

New Cancer Paradigm and New Treatment: The Example of METABLOC

1Ecole Polytechnique, Palaiseau, 91128 Paris, France
2CEREMADE Université Paris Dauphine, 1 Pl Du Mal De Lattre de Tassigny, 75016 Paris, France
3BIOREBUS, 66 avenue des Champs-Elysées lot 41, 75008 Paris, France
4METABLOC Research Center, Centro Medico Kines, Castano Primo (MI), Italy

Received 18 January 2013; Accepted 3 April 2013

Academic Editors: M. Jackson, D. Lee, and A. Szasz

This Conference Paper is based on a presentation given by Laurent Schwartz at “Conference of the International Clinical Hyperthermia Society 2012” held from 12 October 2012 to 14 October 2012 in Budapest, Hungary.

Copyright © 2013 Laurent Schwartz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. O. Warburg, “On the origin of cancer cells,” Science, vol. 123, no. 3191, pp. 309–314, 1956. View at Google Scholar · View at Scopus
  2. M. G. V. Heiden, L. C. Cantley, and C. B. Thompson, “Understanding the warburg effect: the metabolic requirements of cell proliferation,” Science, vol. 324, no. 5930, pp. 1029–1033, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. M. Israël and L. Schwartz, “The metabolic advantage of tumour cells,” Mol Cancer, vol. 10, article 70, 2011. View at Google Scholar
  4. R. B. Robey and N. Hay, “Is Akt the “Warburg kinase”? Akt-energy metabolism interactions and oncogenesis,” Seminars in Cancer Biology, vol. 19, no. 1, pp. 25–31, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. R. Moreno-Sanchez, S. Rodriguez-Enriquez, A. Marin-Hernandez, and E. Saavedra, “Energy metabolism in tumor cells,” FEBS Journal, vol. 274, pp. 1393–1418, 2007. View at Google Scholar
  6. O. Feron, “Pyruvate into lactate and back: from the Warburg effect to symbiotic energy fuel exchange in cancer cells,” Radiotherapy and Oncology, vol. 92, no. 3, pp. 329–333, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. G. Kroemer and J. Pouyssegur, “Tumor Cell Metabolism: Cancer's Achilles' Heel,” Cancer Cell, vol. 13, no. 6, pp. 472–482, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. D. Morvan, J. M. Steyaert, L. Schwartz, M. Israel, and A. Demidem, “Normal human melanocytes exposed to chronic insulin and glucose supplementation undergo oncogenic changes,” American Journal of Physiology. Endocrinology and Metabolism, vol. 302, no. 11, pp. E1407–E1418, 2012. View at Google Scholar
  9. S. Guénin, L. Schwartz, D. Morvan et al., “PP2A activity is controlled by methylation and regulates oncoprotein expression in melanoma cells: a mechanism which participates in growth inhibition induced by chloroethylnitrosourea treatment,” International Journal of Oncology, vol. 32, no. 1, pp. 49–57, 2008. View at Google Scholar · View at Scopus
  10. B. Altenberg and K. O. Greulich, “Genes of glycolysis are ubiquitously overexpressed in 24 cancer classes,” Genomics, vol. 84, no. 6, pp. 1014–1020, 2004. View at Publisher · View at Google Scholar · View at Scopus
  11. R. A. Gatenby and R. J. Gillies, “Why do cancers have high aerobic glycolysis?” Nature Reviews Cancer, vol. 4, no. 11, pp. 891–899, 2004. View at Publisher · View at Google Scholar · View at Scopus
  12. T. Bui and C. B. Thompson, “Cancer's sweet tooth,” Cancer Cell, vol. 9, no. 6, pp. 419–420, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. R. A. Gatenby, E. T. Gawlinski, A. F. Gmitro, B. Kaylor, and R. J. Gillies, “Acid-mediated tumor invasion: a multidisciplinary study,” Cancer Research, vol. 66, no. 10, pp. 5216–5223, 2006. View at Publisher · View at Google Scholar · View at Scopus
  14. S. J. Yeung, J. Pan, and M. H. Lee, “Roles of p53, MYC and HIF-1 in regulating glycolysis—the seventh hallmark of cancer,” Cellular and Molecular Life Sciences, vol. 65, no. 24, pp. 3981–3999, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. H. Pelicano, D. S. Martin, R. H. Xu, and P. Huang, “Glycolysis inhibition for anticancer treatment,” Oncogene, vol. 25, no. 34, pp. 4633–4646, 2006. View at Publisher · View at Google Scholar · View at Scopus
  16. E. D. Michelakis, G. Sutendra, P. Dromparis et al., “Metabolic modulation of glioblastoma with dichloroacetate,” Science Translational Medicine, vol. 13, pp. 31–34, 2010. View at Google Scholar
  17. B. M. Berkson, D. M. Rubin, and A. J. Berkson, “The long-term survival of a patient with pancreatic cancer with metastases to the liver after treatment with the intravenous α-lipoic acid/low-dose naltrexone protocol,” Integrative Cancer Therapies, vol. 5, no. 1, pp. 83–89, 2006. View at Publisher · View at Google Scholar · View at Scopus
  18. B. M. Berkson, D. M. Rubin, and A. J. Berkson, “Revisiting the ALA/N (α-Lipoic Acid/Low-Dose Naltrexone) protocol for people with metastatic and nonmetastatic pancreatic cancer: a report of 3 new cases,” Integrative Cancer Therapies, vol. 8, no. 4, pp. 416–422, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. L. Schwartz, M. Abolhassani, A. Guais et al., “A combination of alpha lipoic acid and calcium hydroxycitrate is efficient against mouse cancer models: preliminary results,” Oncology Reports, vol. 23, no. 5, pp. 1407–1416, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. L. Schwartz, G. Fiorentini, F. Montagnani, A. Guais, and G. Baronzio, “Metastatic cancer response to chemotherapy and METABLOC: a case report,” Journal of Case Reports, 2012. View at Google Scholar
  21. A. Guais, G. Baronzio, E. Sanders et al., “Adding a combination of hydroxycitrate and lipoic acid (METABLOC) to chemotherapy improves effectiveness against tumor development: experimental results and case report,” Investigational New Drugs, vol. 30, no. 1, pp. 200–211, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. G. Baronzio, L. Schwartz, E. Crespi et al., “Early clinical and toxicological results of a combination of natural glycolysis inhibitors (METABLOC) on cancer patients,” Biomedical Research, vol. 23, pp. 219–222, 2012. View at Google Scholar