Biomarker Diagnostics in Acute Cardiac and Noncardiac Dyspnea: Is There a Role for Point-of-Care Testing?

Figure 1

Rapid rule-in and rule-out diagnosis of acute myocardial infarction using high-sensitive troponin T assay. Criteria for rule out: (A) hsTnT <3 ng/L on admission (not part of the guideline!) [10]; (B) no dynamics of hsTnT between admission and 3 h; (C) hsTnT below cutoff value on admission and at 3 h; (D) rise or fall of hsTnT of <20% at 3 h. Criteria for rule in: (E) hsTnT on admission <14 ng/L and rise of >50% at 3 h; (F) hsTnT on admission >14 ng/L and rise or fall of >20% at 3 h; (G) very high hsTnT on admission (level not defined in the guideline, evidence that ~50 ng/L might be a good cutoff value).