Role of Hypertension in Aggravating A Neuropathology of AD Type and Tau-MediatedMotor Impairment
Chronic hypertension aggravated motor deficits assessed by hindlimb extension test in P301L-tau Tg mice. (a) Score scale used to assess motor function of the P301L-tau Tg mice by the hindlimb extension test. (b) Motor function assessed by hindlimb extension test of P301L-tau Tg mice was not affected after inducing hypertension for 5 months (11 months of age), but was significantly aggravated, by 30%, after inducing hypertension for 8 months (14 months of age). Score values represent mean ± SEM of 5 tests. Also , by two-tailed Student's test analysis. (c), (d) Hypertension did not significantly alter tau neuropathology in spinal cords of P301L-tau Tg. (c) Representative Western blot for tau species of WT and P301L-tau Tg (control and hypertensive) spinal cord samples. GAPDH was used as a loading control. (d) Densitometric quantification of the 170 KDa tau species levels in spinal cord samples. Values represent mean ± SEM values. mice per group. Differences between means were analyzed using two-tailed Student’s test versus control mice.
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