Table of Contents
Cardiovascular Psychiatry and Neurology
Volume 2009 (2009), Article ID 187894, 5 pages
http://dx.doi.org/10.1155/2009/187894
Hypothesis

Interleukin-10: A Key Cytokine in Depression?

Life and Health Sciences Research Institute, School of Health Sciences, University of Minho, Campus Gualtar, 4710-057 Braga, Portugal

Received 8 May 2009; Accepted 23 June 2009

Academic Editor: Hari Manev

Copyright © 2009 Susana Roque et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

An increasing body of evidence implicates proinflammatory cytokines in psychiatric disorders, namely, in depression. Of notice, recent studies showed that anti-inflammatory cytokines, such as IL-10, also modulate depressive-like behavior. In this article, we propose that the anti-inflammatory cytokine IL-10 is a putative link between two of the most widely reported phenomenon observed in depressed patients: the disruption of the hypothalamic-pituitary-adrenal axis and the imbalanced production of cytokines. If so, IL-10 might represent a novel target for antidepressant therapy.