The GRK2 Overexpression Is a Primary Hallmark of Mitochondrial Lesions during Early Alzheimer Disease
Figure 2
The ultrastructural localization of GRK2 immunopositive gold particles in postmortem human AD (a) and age-matched control brain (b, c) tissues. (a) The GRK2: immunopositive containing gold particles in the matrix of perivascular pericytes (indicated by single thick arrows) but not in the cytoplasmic matrix of severely damaged vascular endothelium (EC), X 40,000. (b) and (c) The neurons close to perivascular regions show the presence of GRK2 containing gold particles in their matrix, where most gold particles were associated with the neurofibrillary tangle- (NFT-) like structures (arrows). However, the intact mitochondria (M) were free from GRK2-immunopositive gold particles, X 40,000, respectively, (b) and (c). (reprinted with permission of Neurotoxicity Research [8]).
