Review Article

Membrane Omega-3 Fatty Acid Deficiency as a Preventable Risk Factor for Comorbid Coronary Heart Disease in Major Depressive Disorder

Figure 2

Comparison of the “omega-3 index” (RBC EPA+DHA composition) in adult USA patients with acute coronary syndrome (ACS, ) [100], adult MDD patients residing in the USA or UK ( ) [102, 105, 106], healthy adults (HAs) residing in the U.S. ( ) [58], and healthy adults residing in Japan ( ) [57]. Proposed risk zones for sudden cardiac death (SCD) derived from prior prospective longitudinal evidence are indicated [99]. Note that MDD patients exhibit an “omega-3 index” that is similar to patients with ACS and places them at high risk for SCD.
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