Table of Contents
Cardiovascular Psychiatry and Neurology
Volume 2009, Article ID 383086, 3 pages

Do Neural Cells Communicate with Endothelial Cells via Secretory Exosomes and Microvesicles?

Department of Psychiatry, UIC Psychiatric Institute MC912, University of Illinois at Chicago, 1601 W. Taylor Street, Chicago, IL 60612, USA

Received 28 April 2009; Accepted 15 June 2009

Academic Editor: Hari Manev

Copyright © 2009 Neil R. Smalheiser. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Neurons, glial, cells, and brain tumor cells tissues release small vesicles (secretory exosomes and microvesicles), which may represent a novel mechanism by which neuronal activity could influence angiogenesis within the embryonic and mature brain. If CNS-derived vesicles can enter the bloodstream as well, they may communicate with endothelial cells in the peripheral circulation and with cells concerned with immune surveillance.