Table of Contents
Cardiovascular Psychiatry and Neurology
Volume 2009, Article ID 424728, 3 pages
http://dx.doi.org/10.1155/2009/424728
Hypothesis

Possible Role of Platelet GluR1 Receptors in Comorbid Depression and Cardiovascular Disease

Department of Psychiatry, Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, MC912, Chicago, IL 60612, USA

Received 6 May 2009; Accepted 24 June 2009

Academic Editor: Hari Manev

Copyright © 2009 Hu Chen. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. Halaris, “Comorbidity between depression and cardiovascular disease,” International Angiology, vol. 28, no. 2, pp. 92–99, 2009. View at Google Scholar
  2. R. M. Carney, K. E. Freedland, and A. S. Jaffe, “Depression screening in patients with heart disease,” The Journal of the American Medical Association, vol. 301, no. 13, p. 1337, 2009. View at Publisher · View at Google Scholar · View at PubMed
  3. M. A. Whooley, P. de Jonge, E. Vittinghoff et al., “Depressive symptoms, health behaviors, and risk of cardiovascular events in patients with coronary heart disease,” The Journal of the American Medical Association, vol. 300, no. 20, pp. 2379–2388, 2008. View at Publisher · View at Google Scholar · View at PubMed
  4. C. B. Nemeroff and D. L. Musselman, “Are platelets the link between depression and ischemic heart disease?” American Heart Journal, vol. 140, no. 4, supplement, pp. 57–62, 2000. View at Google Scholar
  5. R. Von Känel, J. E. Dimsdale, K. A. Adler, T. L. Patterson, P. J. Mills, and I. Grant, “Effects of depressive symptoms and anxiety on hemostatic responses to acute mental stress and recovery in the elderly,” Psychiatry Research, vol. 126, no. 3, pp. 253–264, 2004. View at Publisher · View at Google Scholar · View at PubMed
  6. K. Aschbacher, S. K. Roepke, R. von Känel et al., “Persistent versus transient depressive symptoms in relation to platelet hyperactivation: a longitudinal analysis of dementia caregivers,” Journal of Affective Disorders, vol. 116, no. 1-2, pp. 80–87, 2009. View at Publisher · View at Google Scholar · View at PubMed
  7. M.-L. Wong, C. Dong, K. Esposito et al., “Elevated stress-hemoconcentration in major depression is normalized by antidepressant treatment: secondary analysis from a randomized, double-blind clinical trial and relevance to cardiovascular disease risk,” PLoS ONE, vol. 3, no. 7, p. e2350, 2008. View at Publisher · View at Google Scholar · View at PubMed
  8. M.-C. Morel-Kopp, L. Mclean, Q. Chen et al., “The association of depression with platelet activation: evidence for a treatment effect,” Journal of Thrombosis and Haemostasis, vol. 7, no. 4, pp. 573–581, 2009. View at Publisher · View at Google Scholar · View at PubMed
  9. D. L. Musselman, A. Tomer, A. K. Manatunga et al., “Exaggerated platelet reactivity in major depression,” American Journal of Psychiatry, vol. 153, no. 10, pp. 1313–1317, 1996. View at Google Scholar
  10. B. G. Pollock, F. Laghrissi-Thode, and W. R. Wagner, “Evaluation of platelet activation in depressed patients with ischemic heart disease after paroxetine or nortriptyline treatment,” Journal of Clinical Psychopharmacology, vol. 20, no. 2, pp. 137–140, 2000. View at Publisher · View at Google Scholar
  11. C. N. Morrell, H. Sun, M. Ikeda et al., “Glutamate mediates platelet activation through the AMPA receptor,” Journal of Experimental Medicine, vol. 205, no. 3, pp. 575–584, 2008. View at Publisher · View at Google Scholar · View at PubMed
  12. K. W. Roche, R. J. O'Brien, A. L. Mammen, J. Bernhardt, and R. L. Huganir, “Characterization of multiple phosphorylation sites on the AMPA receptor GluR1 subunit,” Neuron, vol. 16, no. 6, pp. 1179–1188, 1996. View at Publisher · View at Google Scholar
  13. A. Barria, D. Muller, V. Derkach, L. C. Griffith, and T. R. Soderling, “Regulatory phosphorylation of AMPA-type glutamate receptors by CaM-KII during long-term potentiation,” Science, vol. 276, no. 5321, pp. 2042–2045, 1997. View at Publisher · View at Google Scholar
  14. H. Mitani, Y. Shirayama, T. Yamada, K. Maeda, C. R. Ashby Jr., and R. Kawahara, “Correlation between plasma levels of glutamate, alanine and serine with severity of depression,” Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 30, no. 6, pp. 1155–1158, 2006. View at Publisher · View at Google Scholar · View at PubMed
  15. M. Maes, R. Verkerk, E. Vandoolaeghe, A. Lin, and S. Scharpé, “Serum levels of excitatory amino acids, serine, glycine, histidine, threonine, taurine, alanine and arginine in treatment-resistant depression: modulation by treatment with antidepressants and prediction of clinical responsivity,” Acta Psychiatrica Scandinavica, vol. 97, no. 4, pp. 302–308, 1998. View at Google Scholar
  16. M. Berk, H. Plein, and D. Ferreira, “Platelet glutamate receptor supersensitivity in major depressive disorder,” Clinical Neuropharmacology, vol. 24, no. 3, pp. 129–132, 2001. View at Publisher · View at Google Scholar
  17. J. Q. Wang, A. Arora, L. Yang et al., “Phosphorylation of AMPA receptors: mechanisms and synaptic plasticity,” Molecular Neurobiology, vol. 32, no. 3, pp. 237–249, 2005. View at Publisher · View at Google Scholar · View at PubMed
  18. Y. Dwivedi and G. N. Pandey, “Adenylyl cyclase-cyclicAMP signaling in mood disorders: role of the crucial phosphorylating enzyme protein kinase A,” Neuropsychiatric Disease and Treatment, vol. 4, no. 1 A, pp. 161–176, 2008. View at Google Scholar
  19. T. D. Gould, K. C. O'Donnell, E. R. Dow, J. Du, G. Chen, and H. K. Manji, “Involvement of AMPA receptors in the antidepressant-like effects of lithium in the mouse tail suspension test and forced swim test,” Neuropharmacology, vol. 54, no. 3, pp. 577–587, 2008. View at Publisher · View at Google Scholar · View at PubMed
  20. P. Svenningsson, E. T. Tzavara, J. M. Witkin, A. A. Fienberg, G. G. Nomikos, and P. Greengard, “Involvement of striatal and extrastriatal DARPP-32 in biochemical and behavioral effects of fluoxetine (Prozac),” Proceedings of the National Academy of Sciences of the United States of America, vol. 99, no. 5, pp. 3182–3187, 2002. View at Publisher · View at Google Scholar · View at PubMed
  21. P. Svenningsson, H. Bateup, H. Qi et al., “Involvement of AMPA receptor phosphorylation in antidepressant actions with special reference to tianeptine,” European Journal of Neuroscience, vol. 26, no. 12, pp. 3509–3517, 2007. View at Publisher · View at Google Scholar · View at PubMed
  22. M. Molina-Hernández, N. P. Tellez-Alcántara, J. Pérez-García, J. I. Olivera-Lopez, and M. T. Jaramillo-Jaimes, “Antidepressant-like actions of minocycline combined with several glutamate antagonists,” Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 32, no. 2, pp. 380–386, 2008. View at Publisher · View at Google Scholar · View at PubMed
  23. M. Imbesi, T. Uz, R. Manev, R. P. Sharma, and H. Manev, “Minocycline increases phosphorylation and membrane insertion of neuronal GluR1 receptors,” Neuroscience Letters, vol. 447, no. 2-3, pp. 134–137, 2008. View at Publisher · View at Google Scholar · View at PubMed
  24. S. Maeng, C. A. Zarate Jr., J. Du et al., “Cellular mechanisms underlying the antidepressant effects of ketamine: role of α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors,” Biological Psychiatry, vol. 63, no. 4, pp. 349–352, 2008. View at Publisher · View at Google Scholar · View at PubMed
  25. D. Halperin and G. Reber, “Influence of antidepressants on hemostasis,” Dialogues in Clinical Neuroscience, vol. 9, no. 1, pp. 47–59, 2007. View at Google Scholar
  26. W. H. Sauer, J. A. Berlin, and S. E. Kimmel, “Effect of antidepressants and their relative affinity for the serotonin transporter on the risk of myocardial infarction,” Circulation, vol. 108, no. 1, pp. 32–36, 2003. View at Publisher · View at Google Scholar · View at PubMed
  27. J. R. Dilks and R. Flaumenhaft, “Fluoxetine (Prozac) augments platelet activation mediated through protease-activated receptors,” Journal of Thrombosis and Haemostasis, vol. 6, no. 4, pp. 705–708, 2008. View at Google Scholar