Cardiovascular Psychiatry and Neurology / 2009 / Article / Fig 1


P 2 X 7 Receptors as a Transducer in the Co-Occurrence of Neurological/Psychiatric and Cardiovascular Disorders: A Hypothesis

Figure 1

Schematic representation of potential interactions between the cardiovascular and nervous systems, which may lead to the co-occurrence of cardiovascular, neurological, and psychiatric disorders. In this hypothesis, the P2X7 purinergic receptor plays a pivotal role in linking these disorders, as a result of elevated levels of extracellular ATP and the release of proinflammatory cytokines such as interleukin-1 (IL-1 ) and tumor necrosis factor- (TNF- ). AD, Alzheimer's disease.

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