Table of Contents
Cardiovascular Psychiatry and Neurology
Volume 2009 (2009), Article ID 849519, 5 pages
http://dx.doi.org/10.1155/2009/849519
Hypothesis

Putative Role of MicroRNA-Regulated Pathways in Comorbid Neurological and Cardiovascular Disorders

1Centre de Recherche du CHUQ (CHUL), Axe Neurosciences, Canada
2Département de Biologie Médicale, Université Laval, Laval, QC, G1k 7P4, Canada

Received 27 May 2009; Revised 26 June 2009; Accepted 2 July 2009

Academic Editor: Hari Manev

Copyright © 2009 Sébastien S. Hébert. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. The conserved noncoding microRNAs (miRNAs) that function to regulate gene expression are essential for the development and function of the brain and heart. Changes in miRNA expression profiles are associated with an increased risk for developing neurodegenerative disorders as well as heart failure. Here, the hypothesis of how miRNA-regulated pathways could contribute to comorbid neurological and cardiovascular disorders will be discussed. Presentation. Changes in miRNA expression occurring in the brain and heart could have an impact on coexisting neurological and cardiovascular characteristics by (1) modulating organ function, (2) accentuating cellular stress, and (3) impinging on neuronal and/or heart cell survival. Testing. Evaluation of miRNA expression profiles in the brain and heart tissues from individuals with comorbid neurodegenerative and cardiovascular disorders will be of great importance and relevance. Implications. Careful experimental design will shed light to the deeper understanding of the molecular mechanisms tying up those different but yet somehow connected diseases.