Table of Contents
Cardiovascular Psychiatry and Neurology
Volume 2010, Article ID 396282, 7 pages
http://dx.doi.org/10.1155/2010/396282
Research Article

Serotonin Transporter Clustering in Blood Lymphocytes of Reeler Mice

BIOFARMA Research Group, Department of Cell Biology, Faculty of Biology, University of Santiago de Compostela, Santiago de Compostela, 15782 Galicia, Spain

Received 21 December 2009; Accepted 10 February 2010

Academic Editor: Milos Ikonomovic

Copyright © 2010 Tania Rivera-Baltanas et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Serotonin transporter clustering is an important feature for regulation of this transporter activity. We used immunocytochemistry to analyze alterations in serotonin transporter clustering in blood lymphocytes of reeler mice. Serotonin transporter immunolabelling is observed mostly as a patchy staining in lymphocytes membranes. Comparison of the number and size of serotonin transporter clusters in wild-type mice, heterozygous reeler mice, and homozygous reeler mice showed an increase in the number and size of clusters in heterozygous reeler mice, but only an increase in clusters size in homozygous reeler mice. Reelin is down-regulated in the brain of schizophrenia, autism, and mood disorders, and is also expressed in blood plasma. There is the possibility therefore that alterations in serotonin transporter clustering in blood lymphocytes associated with a decrease in reelin expression may be operative in some cardiovascular or immune system alterations showing comorbidity with these mental disorders.