Table of Contents
Cardiovascular Psychiatry and Neurology
Volume 2010, Article ID 703563, 5 pages
Review Article

Perinatal S100B Protein Assessment in Human Unconventional Biological Fluids: A Minireview and New Perspectives

1Department of Maternal, Fetal and Neonatal Medicine, C. Arrigo Children's Hospital, Alessandria, Italy
2Research Laboratory, Department of Cardiac Surgery, San Donato University Hospital, San Donato Milanese, Italy
3Institute of Anatomy and Cell Biology, Catholic University of the Sacred Heart, Largo Francesco Vito, 1, I-00168 Rome, Italy

Received 1 April 2010; Accepted 3 May 2010

Academic Editor: Claus W. Heizmann

Copyright © 2010 Diego Gazzolo and Fabrizio Michetti. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Growing evidence is now available on the use of S100B protein as a valuable marker of brain damage and its role as a neurotrophic factor. Bearing in mind, among different S100B protein properties that are still being investigated, the possibility of measuring this protein in different biological fluids renders it suitable for use in several disciplines. This is the case with perinatal medicine where even more noninvasive techniques are particularly desirable in order to ensure the minimal handling diagnostic and therapeutic strategies. In this setting, the present minireview reports data on the presence and the usefulness of S100B protein as brain damage marker and as a neurotrophic factor in the so-called unconventional biological fluids such as saliva and human milk, respectively. Results offer new possibilities for the use of S100B in perinatal medicine as a key-protein for the investigations focusing on central nervous system development and damage.