Table of Contents
Cardiovascular Psychiatry and Neurology
Volume 2010, Article ID 801295, 8 pages
Clinical Study

The Passage of S100B from Brain to Blood Is Not Specifically Related to the Blood-Brain Barrier Integrity

1Department of Neurosurgery, University Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
2Institute of Laboratory Medicine, University Erlangen-Nuremberg, 91054 Erlangen, Germany

Received 28 February 2010; Revised 12 May 2010; Accepted 24 May 2010

Academic Editor: Rosario Donato

Copyright © 2010 Andrea Kleindienst et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Following brain injury, S100B is released from damaged astrocytes but also yields repair mechanisms. We measured S100B in the cerebrospinal fluid (CSF) and serum (Cobas e411 electrochemiluminescence assay, Roche) longitudinally in a large cohort of patients treated with a ventricular drainage following traumatic brain injury (TBI) or subarachnoid hemorrhage (SAH). Statistical analysis was performed with SPSS software applying the Mann-Whitney rank sum test or chi-test where appropriate. S100B in CSF and serum was significantly increased following TBI ( ) and SAH ( ) for at least one week following injury. High S100B levels in CSF and serum were inconsistent associated with outcome. The passage of S100B from CSF to blood ( ) was significantly decreased although the albumin quotient suggested an “open” blood-CSF barrier. Events possibly interfering with the BBB did not affect the S100B passage ( ). In conclusion, we could not confirm S100B measurements to reliably predict outcome, and a compromised blood-CSF barrier did not affect the passage of S100B from CSF to serum.