Effects of Neonatal Systemic Inflammation on Blood-Brain Barrier Permeability and Behaviour in Juvenile and Adult Rats
Figure 2
The behaviour of P20 and adult animals in a stressful environment was determined in an arena where half was brightly lit and the other half was dark and enclosed. Total moves (a) and entries into the light half and the vertical plane were determined (b), as well as time spent in the light half and latency (c). P20 animals exposed to LPS during postnatal development showed a small but significant decrease in total movement in this apparatus, but otherwise showed no changes compared to saline-injected controls ( for each group). Adult animals treated with LPS showed increased exploratory behaviour with increased time and entries into the light half of the arena, reduced latency to enter the light half and increased vertical plane entries (*, data are mean ± SEM, for each group).
